Ultrasound-stimulated drug delivery of reconstituted high density lipoprotein nanoparticles: Effects of drug concentration on tumor uptake

Fangyuan Xiong, Mouna Xiong, Sabnis Nirupama, Shashank Sirsi, Andras Lacko, Kenneth Hoyt

Research output: Chapter in Book/Report/Conference proceedingConference contribution

1 Scopus citations

Abstract

The abnormal vasculature of tumor and the resulting abnormal microenvironment is a major barrier to optimal chemotherapeutic drug delivery. It is well known that ultrasound (US) can increase the permeability of the tumor vessel walls and enhance the accumulation of anticancer drugs. Reconstituted high density lipoproteins (rHDL) nanoparticles (NPs) allow selective delivery of anticancer agents to tumor cells via their overexpressed SR-B1 receptor. The goal of this study is to investigate the potential of noninvasive US therapy to further improve delivery and tumor uptake of rHDL NPs preloaded with an infrared dye (IR780), which is devoted to the establishment of a surrogate chemotherapeutic model with optical localization.

Original languageEnglish (US)
Title of host publication2017 IEEE International Ultrasonics Symposium, IUS 2017
PublisherIEEE Computer Society
ISBN (Electronic)9781538633830
DOIs
StatePublished - Oct 31 2017
Event2017 IEEE International Ultrasonics Symposium, IUS 2017 - Washington, United States
Duration: Sep 6 2017Sep 9 2017

Other

Other2017 IEEE International Ultrasonics Symposium, IUS 2017
CountryUnited States
CityWashington
Period9/6/179/9/17

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ASJC Scopus subject areas

  • Acoustics and Ultrasonics

Cite this

Xiong, F., Xiong, M., Nirupama, S., Sirsi, S., Lacko, A., & Hoyt, K. (2017). Ultrasound-stimulated drug delivery of reconstituted high density lipoprotein nanoparticles: Effects of drug concentration on tumor uptake. In 2017 IEEE International Ultrasonics Symposium, IUS 2017 [8092380] IEEE Computer Society. https://doi.org/10.1109/ULTSYM.2017.8092380