Ultrasound therapy amplifies chemotherapeutic effectiveness in head and neck cancer

Anna G. Sorace, Joseph Knowles, Cara Heath, Eben Rosenthal, Kenneth Hoyt

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Microbubble (MB) mediated ultrasound (US) therapy is a novel technique to non-invasively enhance cancer treatment by increasing cell membrane permeability and vascular extravasation. The objective of this experiment is to determine if MB-mediated US therapy can improve cancer therapy, specifically cisplatin or cetuximab, in head and neck cancer. In vitro experiments included combination chemotherapy and MB-mediated US therapy on head and neck cancer cell line, SCC-5, and dose curve responses to therapy. In vivo experimentation included a four week study of MB-mediated US therapy compared to current standard therapy of drug alone. Monitoring of tumor response to therapy included caliper measurements, diffusion-weighted magnetic resonance (DW-MR) imaging, and immunohistologic analysis. Anti-tumor effects increased by over 50% when combining MB-mediated US therapy with cetuximab and cisplatin (P = 0.01, P = 0.02). MB-mediated US therapy was seen to produce as additive effect by increasing localized delivery of drug in head and neck cancer. This technique shows potential for improved localized therapy in cancer.

Original languageEnglish (US)
Title of host publication2012 IEEE International Ultrasonics Symposium, IUS 2012
Pages433-435
Number of pages3
DOIs
Publication statusPublished - Dec 1 2012
Event2012 IEEE International Ultrasonics Symposium, IUS 2012 - Dresden, Germany
Duration: Oct 7 2012Oct 10 2012

Other

Other2012 IEEE International Ultrasonics Symposium, IUS 2012
CountryGermany
CityDresden
Period10/7/1210/10/12

    Fingerprint

ASJC Scopus subject areas

  • Acoustics and Ultrasonics

Cite this

Sorace, A. G., Knowles, J., Heath, C., Rosenthal, E., & Hoyt, K. (2012). Ultrasound therapy amplifies chemotherapeutic effectiveness in head and neck cancer. In 2012 IEEE International Ultrasonics Symposium, IUS 2012 (pp. 433-435). [6562470] https://doi.org/10.1109/ULTSYM.2012.0107