Ultrastructural detection of granulated cells in the autonomic ganglia of the rat pancreas

D. Baetens, M. Vasko, Roger H Unger, L. Orci

Research output: Contribution to journalArticle

8 Scopus citations

Abstract

Electron microscopic examination of the intrinsic autonomic ganglia of the rat pancreas revealed the presence of small cells, when compared to the principal ganglionic neurons, within a particular type of ganglia. The small cells were often located in clusters around fenestrated capillaries, but their most striking characteristic was the presence of catecholamine-like granules distributed throughout the cytoplasm. The possible implication of this new source of catecholamines, acting either as interneurons or as neuroendocrine cells, is discussed in the light of a local regulatory mechanism for islet secretion.

Original languageEnglish (US)
Pages (from-to)841-846
Number of pages6
JournalDiabetologia
Volume28
Issue number11
DOIs
StatePublished - Nov 1 1985

Keywords

  • Autonomic nervous system
  • catecholamines
  • electron microscopy
  • intrinsic ganglia
  • islets of Langerhans
  • small granulated cells

ASJC Scopus subject areas

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism

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