Umbilicial cord plasma levels of dehydroepiandrosterone sulfate during human gestation

C. R. Parker, K. Leveno, B. R. Carr

Research output: Contribution to journalArticle

48 Citations (Scopus)

Abstract

In the current investigation we sought to evaluate fetal adrenal dehydroepiandrosterone sulfate (DS) production during normal human pregnancy. We found that the mean umbilicaal cord plasma concentration of DS was reasonably constant from 18-34 weeks of gestation, ranging from 1131-1517 ng/ml. Thereafter, the cord plasma DS concentration rose steadily to 2463 ± 665 ng/ml (mean ± SD) at 39-40 weeks of gestation. Between 20 and 32 weeks of gestation, the estimated fetal plasma DS pool increased from 8 to 146 μg. At term, the estimated fetal DS plasma pool was in excess of 300 μg. From 34-40 weeks of gestation, the estimated fetal DS pool size and the fetal plasma DS concentration increased coincidentally with a marked rise in the known rate of fetal adrenal growth. From these findings, we conclude that fetal adrenal DS production increases steadily throughout gestation, and the rate of increase is probably dependent upon the rate of fetal adrenal growth. Furthermore, the rapid increase in maternal estrogen levels near term observed by numerous investigators can be explained in part by an increased availability of the fetal estrogen precursor DS at this time.

Original languageEnglish (US)
Pages (from-to)1216-1220
Number of pages5
JournalJournal of Clinical Endocrinology and Metabolism
Volume54
Issue number6
StatePublished - 1982

Fingerprint

Dehydroepiandrosterone Sulfate
Plasmas
Pregnancy
Fetal Development
Estrogens
Mothers
Research Personnel
Availability

ASJC Scopus subject areas

  • Biochemistry
  • Endocrinology, Diabetes and Metabolism

Cite this

Umbilicial cord plasma levels of dehydroepiandrosterone sulfate during human gestation. / Parker, C. R.; Leveno, K.; Carr, B. R.

In: Journal of Clinical Endocrinology and Metabolism, Vol. 54, No. 6, 1982, p. 1216-1220.

Research output: Contribution to journalArticle

@article{87320a4841fb4545a8b794e17aa592e0,
title = "Umbilicial cord plasma levels of dehydroepiandrosterone sulfate during human gestation",
abstract = "In the current investigation we sought to evaluate fetal adrenal dehydroepiandrosterone sulfate (DS) production during normal human pregnancy. We found that the mean umbilicaal cord plasma concentration of DS was reasonably constant from 18-34 weeks of gestation, ranging from 1131-1517 ng/ml. Thereafter, the cord plasma DS concentration rose steadily to 2463 ± 665 ng/ml (mean ± SD) at 39-40 weeks of gestation. Between 20 and 32 weeks of gestation, the estimated fetal plasma DS pool increased from 8 to 146 μg. At term, the estimated fetal DS plasma pool was in excess of 300 μg. From 34-40 weeks of gestation, the estimated fetal DS pool size and the fetal plasma DS concentration increased coincidentally with a marked rise in the known rate of fetal adrenal growth. From these findings, we conclude that fetal adrenal DS production increases steadily throughout gestation, and the rate of increase is probably dependent upon the rate of fetal adrenal growth. Furthermore, the rapid increase in maternal estrogen levels near term observed by numerous investigators can be explained in part by an increased availability of the fetal estrogen precursor DS at this time.",
author = "Parker, {C. R.} and K. Leveno and Carr, {B. R.}",
year = "1982",
language = "English (US)",
volume = "54",
pages = "1216--1220",
journal = "Journal of Clinical Endocrinology and Metabolism",
issn = "0021-972X",
publisher = "The Endocrine Society",
number = "6",

}

TY - JOUR

T1 - Umbilicial cord plasma levels of dehydroepiandrosterone sulfate during human gestation

AU - Parker, C. R.

AU - Leveno, K.

AU - Carr, B. R.

PY - 1982

Y1 - 1982

N2 - In the current investigation we sought to evaluate fetal adrenal dehydroepiandrosterone sulfate (DS) production during normal human pregnancy. We found that the mean umbilicaal cord plasma concentration of DS was reasonably constant from 18-34 weeks of gestation, ranging from 1131-1517 ng/ml. Thereafter, the cord plasma DS concentration rose steadily to 2463 ± 665 ng/ml (mean ± SD) at 39-40 weeks of gestation. Between 20 and 32 weeks of gestation, the estimated fetal plasma DS pool increased from 8 to 146 μg. At term, the estimated fetal DS plasma pool was in excess of 300 μg. From 34-40 weeks of gestation, the estimated fetal DS pool size and the fetal plasma DS concentration increased coincidentally with a marked rise in the known rate of fetal adrenal growth. From these findings, we conclude that fetal adrenal DS production increases steadily throughout gestation, and the rate of increase is probably dependent upon the rate of fetal adrenal growth. Furthermore, the rapid increase in maternal estrogen levels near term observed by numerous investigators can be explained in part by an increased availability of the fetal estrogen precursor DS at this time.

AB - In the current investigation we sought to evaluate fetal adrenal dehydroepiandrosterone sulfate (DS) production during normal human pregnancy. We found that the mean umbilicaal cord plasma concentration of DS was reasonably constant from 18-34 weeks of gestation, ranging from 1131-1517 ng/ml. Thereafter, the cord plasma DS concentration rose steadily to 2463 ± 665 ng/ml (mean ± SD) at 39-40 weeks of gestation. Between 20 and 32 weeks of gestation, the estimated fetal plasma DS pool increased from 8 to 146 μg. At term, the estimated fetal DS plasma pool was in excess of 300 μg. From 34-40 weeks of gestation, the estimated fetal DS pool size and the fetal plasma DS concentration increased coincidentally with a marked rise in the known rate of fetal adrenal growth. From these findings, we conclude that fetal adrenal DS production increases steadily throughout gestation, and the rate of increase is probably dependent upon the rate of fetal adrenal growth. Furthermore, the rapid increase in maternal estrogen levels near term observed by numerous investigators can be explained in part by an increased availability of the fetal estrogen precursor DS at this time.

UR - http://www.scopus.com/inward/record.url?scp=0020335831&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0020335831&partnerID=8YFLogxK

M3 - Article

C2 - 6210707

AN - SCOPUS:0020335831

VL - 54

SP - 1216

EP - 1220

JO - Journal of Clinical Endocrinology and Metabolism

JF - Journal of Clinical Endocrinology and Metabolism

SN - 0021-972X

IS - 6

ER -