Unbiased Identification of trans Regulators of ADAR and A-to-I RNA Editing

Emily C. Freund, Anne L. Sapiro, Qin Li, Sandra Linder, James J. Moresco, John R. Yates, Jin Billy Li

Research output: Contribution to journalArticlepeer-review

5 Scopus citations


RNA editing is an essential cellular process mediated by ADARs, but few trans regulators are known. Freund et al. use BioID to identify ADAR interactors, including all DZF-domain-containing proteins. One of these, ILF3, is shown to be a global negative regulator of editing, establishing this family as influential editing regulators.

Original languageEnglish (US)
Article number107656
JournalCell Reports
Issue number7
StatePublished - May 19 2020
Externally publishedYes


  • A-to-I RNA editing
  • ADAR
  • BioID
  • BirA
  • DZF-domain
  • ILF2
  • ILF3
  • ZFR

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)


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