Unbiased Identification of trans Regulators of ADAR and A-to-I RNA Editing

Emily C. Freund; Anne L. Sapiro; Qin Li; Sandra Linder; James J. Moresco; John R. Yates; Jin Billy Li

doi:10.1016/j.celrep.2020.107656

Unbiased Identification of trans Regulators of ADAR and A-to-I RNA Editing

Emily C. Freund, Anne L. Sapiro, Qin Li, Sandra Linder, James J. Moresco, John R. Yates, Jin Billy Li

Research output: Contribution to journal › Article › peer-review

31 Scopus citations

Abstract

RNA editing is an essential cellular process mediated by ADARs, but few trans regulators are known. Freund et al. use BioID to identify ADAR interactors, including all DZF-domain-containing proteins. One of these, ILF3, is shown to be a global negative regulator of editing, establishing this family as influential editing regulators.

Original language	English (US)
Article number	107656
Journal	Cell Reports
Volume	31
Issue number	7
DOIs	https://doi.org/10.1016/j.celrep.2020.107656
State	Published - May 19 2020
Externally published	Yes

Keywords

A-to-I RNA editing
ADAR
BioID
BirA
DZF-domain
ILF2
ILF3
STRBP
ZFR

ASJC Scopus subject areas

General Biochemistry, Genetics and Molecular Biology

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10.1016/j.celrep.2020.107656

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title = "Unbiased Identification of trans Regulators of ADAR and A-to-I RNA Editing",

abstract = "RNA editing is an essential cellular process mediated by ADARs, but few trans regulators are known. Freund et al. use BioID to identify ADAR interactors, including all DZF-domain-containing proteins. One of these, ILF3, is shown to be a global negative regulator of editing, establishing this family as influential editing regulators.",

keywords = "A-to-I RNA editing, ADAR, BioID, BirA, DZF-domain, ILF2, ILF3, STRBP, ZFR",

author = "Freund, {Emily C.} and Sapiro, {Anne L.} and Qin Li and Sandra Linder and Moresco, {James J.} and Yates, {John R.} and Li, {Jin Billy}",

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language = "English (US)",

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AU - Freund, Emily C.

AU - Sapiro, Anne L.

AU - Li, Qin

AU - Linder, Sandra

AU - Moresco, James J.

AU - Yates, John R.

AU - Li, Jin Billy

PY - 2020/5/19

Y1 - 2020/5/19

N2 - RNA editing is an essential cellular process mediated by ADARs, but few trans regulators are known. Freund et al. use BioID to identify ADAR interactors, including all DZF-domain-containing proteins. One of these, ILF3, is shown to be a global negative regulator of editing, establishing this family as influential editing regulators.

AB - RNA editing is an essential cellular process mediated by ADARs, but few trans regulators are known. Freund et al. use BioID to identify ADAR interactors, including all DZF-domain-containing proteins. One of these, ILF3, is shown to be a global negative regulator of editing, establishing this family as influential editing regulators.

KW - A-to-I RNA editing

KW - ADAR

KW - BioID

KW - BirA

KW - DZF-domain

KW - ILF2

KW - ILF3

KW - STRBP

KW - ZFR

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SN - 2211-1247

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JO - Cell Reports

JF - Cell Reports

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ER -

Unbiased Identification of trans Regulators of ADAR and A-to-I RNA Editing

Abstract

Keywords

ASJC Scopus subject areas

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