Unbiased Identification of trans Regulators of ADAR and A-to-I RNA Editing

Emily C. Freund, Anne L. Sapiro, Qin Li, Sandra Linder, James J. Moresco, John R. Yates, Jin Billy Li

Research output: Contribution to journalArticle

1 Scopus citations

Abstract

RNA editing is an essential cellular process mediated by ADARs, but few trans regulators are known. Freund et al. use BioID to identify ADAR interactors, including all DZF-domain-containing proteins. One of these, ILF3, is shown to be a global negative regulator of editing, establishing this family as influential editing regulators.

Original languageEnglish (US)
Article number107656
JournalCell Reports
Volume31
Issue number7
DOIs
StatePublished - May 19 2020

Keywords

  • A-to-I RNA editing
  • ADAR
  • BioID
  • BirA
  • DZF-domain
  • ILF2
  • ILF3
  • STRBP
  • ZFR

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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    Freund, E. C., Sapiro, A. L., Li, Q., Linder, S., Moresco, J. J., Yates, J. R., & Li, J. B. (2020). Unbiased Identification of trans Regulators of ADAR and A-to-I RNA Editing. Cell Reports, 31(7), [107656]. https://doi.org/10.1016/j.celrep.2020.107656