TY - JOUR
T1 - Uncorrected wavefront error and visual performance during RGP wear in keratoconus
AU - Marsack, Jason D.
AU - Parker, Katrina E.
AU - Pesudovs, Konrad
AU - Donnelly, William J.
AU - Applegate, Raymond A.
PY - 2007/6
Y1 - 2007/6
N2 - PURPOSE. To examine the relationship between uncorrected residual wavefront error and visual performance (VP) in rigid gas permeable (RGP) contact lens-wearing keratoconic eyes. METHODS. Seven eyes from six subjects (six moderate, one severe) were studied (mean ± SD age: 42.71 ± 11.38 years). Significant corneal scarring was an exclusion criterion. Measurements were taken with RGP lenses in place. After pupil dilation, the VP measures of high contrast logMAR visual acuity (VA) and Pelli-Robson contrast sensitivity (PRCS) were measured through a 5-mm artificial pupil. Wavefront error was measured using a Shack-Hartmann wavefront sensor and calculated over 5 mm. For both VP and wavefront error, comparisons were made to previously collected normal values by calculating the interval encompassing 95% of normals, then reporting how many of the seven keratoconic eyes fell outside the normal interval. Additionally, second to sixth order aberrations were processed into four previously reported image quality metrics: root mean square of the wavefront (RMSw), root mean square of the slope (RMSs), average blur strength (Bave) and diameter containing 50% light energy (D50) and regressed against VP measures. RESULTS. Five of seven keratoconic eyes fell outside the normal interval (-0.23 to 0.09) for VA and two of seven fell outside the normal interval (1.59 to 2.03) for PRCS. Five of seven keratoconic eyes fell outside the normal interval (0.07 to 0.35 μm) for total higher order RMS. Linear regressions demonstrated relationships between both VA and PRCS and the image quality metrics RMSw, D50, RMSs, and Bave with R values for VA = 0.30, 0.30, 0.47, 0.62, and PRCS = 0.21, 0.15, 0.45, 0.75 respectively. CONCLUSIONS. VP in RGP-wearing keratoconic eyes is reduced and higher order wavefront aberrations are elevated compared to normals. Metrics of retinal image quality demonstrate a relationship between keratoconic VP and residual wavefront aberrations. This relationship suggests developing corrections that more completely correct aberrations may improve visual performance in keratoconus.
AB - PURPOSE. To examine the relationship between uncorrected residual wavefront error and visual performance (VP) in rigid gas permeable (RGP) contact lens-wearing keratoconic eyes. METHODS. Seven eyes from six subjects (six moderate, one severe) were studied (mean ± SD age: 42.71 ± 11.38 years). Significant corneal scarring was an exclusion criterion. Measurements were taken with RGP lenses in place. After pupil dilation, the VP measures of high contrast logMAR visual acuity (VA) and Pelli-Robson contrast sensitivity (PRCS) were measured through a 5-mm artificial pupil. Wavefront error was measured using a Shack-Hartmann wavefront sensor and calculated over 5 mm. For both VP and wavefront error, comparisons were made to previously collected normal values by calculating the interval encompassing 95% of normals, then reporting how many of the seven keratoconic eyes fell outside the normal interval. Additionally, second to sixth order aberrations were processed into four previously reported image quality metrics: root mean square of the wavefront (RMSw), root mean square of the slope (RMSs), average blur strength (Bave) and diameter containing 50% light energy (D50) and regressed against VP measures. RESULTS. Five of seven keratoconic eyes fell outside the normal interval (-0.23 to 0.09) for VA and two of seven fell outside the normal interval (1.59 to 2.03) for PRCS. Five of seven keratoconic eyes fell outside the normal interval (0.07 to 0.35 μm) for total higher order RMS. Linear regressions demonstrated relationships between both VA and PRCS and the image quality metrics RMSw, D50, RMSs, and Bave with R values for VA = 0.30, 0.30, 0.47, 0.62, and PRCS = 0.21, 0.15, 0.45, 0.75 respectively. CONCLUSIONS. VP in RGP-wearing keratoconic eyes is reduced and higher order wavefront aberrations are elevated compared to normals. Metrics of retinal image quality demonstrate a relationship between keratoconic VP and residual wavefront aberrations. This relationship suggests developing corrections that more completely correct aberrations may improve visual performance in keratoconus.
KW - Aberration
KW - Keratoconus
KW - Optical quality metrics
KW - Visual performance
KW - Zernike polynomial
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U2 - 10.1097/OPX.0b013e31802e64f0
DO - 10.1097/OPX.0b013e31802e64f0
M3 - Article
C2 - 17568315
AN - SCOPUS:34250764945
SN - 1040-5488
VL - 84
SP - 463
EP - 470
JO - Optometry and Vision Science
JF - Optometry and Vision Science
IS - 6
ER -