TY - JOUR
T1 - Under-reporting of Parkinson's disease on death certificates
T2 - A population-based study (NEDICES)
AU - Benito-León, Julián
AU - Louis, Elan D.
AU - Villarejo-Galende, Alberto
AU - Romero, Juan Pablo
AU - Bermejo-Pareja, Félix
N1 - Funding Information:
Additional information about collaborators and detailed funding of the NEDICES Study can be found on the web ( http://www.ciberned.es/estudio-nedices ). The Spanish Health Research Agency and the Spanish Office of Science and Technology supported NEDICES. Dr. Benito-León is supported by the National Institutes of Health, Bethesda, MD, USA (NINDS # R01 NS039422 ), the Commission of the European Union (grant ICT-2011-287739 , NeuroTREMOR), and the Spanish Health Research Agency (grant FIS PI12/01602 ). Dr. Elan D. Louis has received research support from the National Institutes of Health, Bethesda, MD, USA: NINDS # R01 NS042859 (principal investigator), NINDS # R01 NS39422 (principal investigator), NINDS # T32 NS07153-24 (principal investigator), NINDS # R01 NS073872 (principal investigator), NINDS # R21 NS077094 (co-Investigator), and NINDS # R01 NS36630 (co-Investigator), as well as the Parkinson's Disease Foundation (principal investigator). Dr. Bermejo-Pareja is supported by the National Institutes of Health, Bethesda, MD, USA (NINDS # R01 NS039422 ) and the Commission of the European Union (grant ICT-2011-287739 , NeuroTREMOR).
Publisher Copyright:
© 2014 Elsevier B.V. All rights reserved.
PY - 2014/12/15
Y1 - 2014/12/15
N2 - Background Parkinson's disease is frequently omitted as a cause of death from death certificates. A limitation of previous studies that attempted to assess the validity of death certificates is that population-dwelling cases, with milder, undiagnosed Parkinson's disease were likely excluded. As a result, those studies likely overestimated the validity of death certificates because they did not include these milder cases. We assessed the validity of death certificates in a prospective population-based study (NEDICES), which includes previously undiagnosed Parkinson's disease cases detected during the assessment.Methods 3926 community-dwelling elderly subjects with and without Parkinson's disease were followed during a median of 12.6 years, after which the death certificates of those who died were examined. We calculated the proportion of cases of clinically diagnosed Parkinson's disease for whom a diagnosis of Parkinson's disease was certified as the basic cause of death on death certificates.Results 1791 (45.6%) of the 3926 participants died over a median follow-up of 7.1 years, including 82 (73.9%) deaths among 111 participants with Parkinson's disease. Parkinson's disease was rarely certified as the basic cause of death (14.6%). Gender, disease stage and the period during which the study was conducted (i.e., 1994 to 2007) did not influence the likelihood that Parkinson's disease would be reported.Conclusions Our findings reinforce the notion that the reporting of Parkinson's disease on death certificates remains poor. This suggests a lack of awareness of the importance of Parkinson's disease as a cause of death.
AB - Background Parkinson's disease is frequently omitted as a cause of death from death certificates. A limitation of previous studies that attempted to assess the validity of death certificates is that population-dwelling cases, with milder, undiagnosed Parkinson's disease were likely excluded. As a result, those studies likely overestimated the validity of death certificates because they did not include these milder cases. We assessed the validity of death certificates in a prospective population-based study (NEDICES), which includes previously undiagnosed Parkinson's disease cases detected during the assessment.Methods 3926 community-dwelling elderly subjects with and without Parkinson's disease were followed during a median of 12.6 years, after which the death certificates of those who died were examined. We calculated the proportion of cases of clinically diagnosed Parkinson's disease for whom a diagnosis of Parkinson's disease was certified as the basic cause of death on death certificates.Results 1791 (45.6%) of the 3926 participants died over a median follow-up of 7.1 years, including 82 (73.9%) deaths among 111 participants with Parkinson's disease. Parkinson's disease was rarely certified as the basic cause of death (14.6%). Gender, disease stage and the period during which the study was conducted (i.e., 1994 to 2007) did not influence the likelihood that Parkinson's disease would be reported.Conclusions Our findings reinforce the notion that the reporting of Parkinson's disease on death certificates remains poor. This suggests a lack of awareness of the importance of Parkinson's disease as a cause of death.
KW - Death certificates
KW - Elderly
KW - Epidemiology
KW - Parkinson's disease
KW - Population-based study
KW - Under-reporting
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U2 - 10.1016/j.jns.2014.08.048
DO - 10.1016/j.jns.2014.08.048
M3 - Article
C2 - 25292414
AN - SCOPUS:84920124216
VL - 347
SP - 188
EP - 192
JO - Journal of the Neurological Sciences
JF - Journal of the Neurological Sciences
SN - 0022-510X
IS - 1-2
ER -