Understanding the association between chromosomally integrated human herpesvirus 6 and HIV disease: A cross-sectional study

Mundeep K. Kainth; Susan G. Fisher; Diana Fernandez; Amneris Luque; Caroline B. Hall; Anh Thi Hoang; Anisha Lashkari; Alexandra Peck; Lubaba Hasan; Mary T. Caserta

doi:10.12688/f1000research.2-269.v2

Understanding the association between chromosomally integrated human herpesvirus 6 and HIV disease: A cross-sectional study

Mundeep K. Kainth, Susan G. Fisher, Diana Fernandez, Amneris Luque, Caroline B. Hall, Anh Thi Hoang, Anisha Lashkari, Alexandra Peck, Lubaba Hasan, Mary T. Caserta

Research output: Contribution to journal › Article › peer-review

1 Scopus citations

Abstract

We conducted a cross-sectional investigation to identify evidence of a potential modifying effect of chromosomally integrated human herpes virus 6 (ciHHV-6) on human immunodeficiency virus (HIV) disease progression and/or severity. ciHHV-6 was identified by detecting HHV-6 DNA in hair follicle specimens of 439 subjects. There was no statistically significant relationship between the presence of ciHHV-6 and HIV disease progression to acquired immunodeficiency syndrome. However, after adjusting for use of antiretroviral therapy, all subjects with ciHHV-6 had low severity HIV disease; these findings were not statistically significant. A multi-center study with a larger sample size will be needed to more precisely determine if there is an association between ciHHV-6 and low HIV disease severity.

Original language	English (US)
Article number	269
Journal	F1000Research
Volume	2
DOIs	https://doi.org/10.12688/f1000research.2-269.v2
State	Published - 2017

ASJC Scopus subject areas

Biochemistry, Genetics and Molecular Biology(all)
Immunology and Microbiology(all)
Pharmacology, Toxicology and Pharmaceutics(all)

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Understanding the association between chromosomally integrated human herpesvirus 6 and HIV disease : A cross-sectional study. / Kainth, Mundeep K.; Fisher, Susan G.; Fernandez, Diana; Luque, Amneris; Hall, Caroline B.; Hoang, Anh Thi; Lashkari, Anisha; Peck, Alexandra; Hasan, Lubaba; Caserta, Mary T.

In: F1000Research, Vol. 2, 269, 2017.

Research output: Contribution to journal › Article › peer-review

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title = "Understanding the association between chromosomally integrated human herpesvirus 6 and HIV disease: A cross-sectional study",

abstract = "We conducted a cross-sectional investigation to identify evidence of a potential modifying effect of chromosomally integrated human herpes virus 6 (ciHHV-6) on human immunodeficiency virus (HIV) disease progression and/or severity. ciHHV-6 was identified by detecting HHV-6 DNA in hair follicle specimens of 439 subjects. There was no statistically significant relationship between the presence of ciHHV-6 and HIV disease progression to acquired immunodeficiency syndrome. However, after adjusting for use of antiretroviral therapy, all subjects with ciHHV-6 had low severity HIV disease; these findings were not statistically significant. A multi-center study with a larger sample size will be needed to more precisely determine if there is an association between ciHHV-6 and low HIV disease severity.",

author = "Kainth, {Mundeep K.} and Fisher, {Susan G.} and Diana Fernandez and Amneris Luque and Hall, {Caroline B.} and Hoang, {Anh Thi} and Anisha Lashkari and Alexandra Peck and Lubaba Hasan and Caserta, {Mary T.}",

note = "Funding Information: Competing interests: Mary T. Caserta has received funding from the HHV-6 Foundation for unrelated projects. No other competing interests were disclosed. Funding Information: Grant information: Mundeep K. Kainth received a Strong Children{\textquoteright}s Research Center Bradford Fellowship and a Developmental Center for AIDS Research pilot award. She was supported by NIH/NIAID 2 T32 AI 007464-16 during her fellowship training. Funding Information: Mary T. Caserta has received funding from the HHV-6 Foundation for unrelated projects. No other competing interests were disclosed. Funding Information: Mundeep K. Kainth received a Strong Children{\textquoteright}s Research Center Bradford Fellowship and a Developmental Center for AIDS Research pilot award. She was supported by NIH/NIAID 2 T32 AI 007464-16 during her fellowship training.",

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AU - Luque, Amneris

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AU - Lashkari, Anisha

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AU - Hasan, Lubaba

AU - Caserta, Mary T.

N1 - Funding Information: Competing interests: Mary T. Caserta has received funding from the HHV-6 Foundation for unrelated projects. No other competing interests were disclosed. Funding Information: Grant information: Mundeep K. Kainth received a Strong Children’s Research Center Bradford Fellowship and a Developmental Center for AIDS Research pilot award. She was supported by NIH/NIAID 2 T32 AI 007464-16 during her fellowship training. Funding Information: Mary T. Caserta has received funding from the HHV-6 Foundation for unrelated projects. No other competing interests were disclosed. Funding Information: Mundeep K. Kainth received a Strong Children’s Research Center Bradford Fellowship and a Developmental Center for AIDS Research pilot award. She was supported by NIH/NIAID 2 T32 AI 007464-16 during her fellowship training.

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