Understanding the association between chromosomally integrated human herpesvirus 6 and HIV disease: A cross-sectional study

Mundeep K. Kainth; Susan G. Fisher; Diana Fernandez; Amneris Luque; Caroline B. Hall; Anh Thi Hoang; Anisha Lashkari; Alexandra Peck; Lubaba Hasan; Mary T. Caserta

doi:10.12688/f1000research.2-269.v2

Understanding the association between chromosomally integrated human herpesvirus 6 and HIV disease: A cross-sectional study

Mundeep K. Kainth, Susan G. Fisher, Diana Fernandez, Amneris Luque, Caroline B. Hall, Anh Thi Hoang, Anisha Lashkari, Alexandra Peck, Lubaba Hasan, Mary T. Caserta

Research output: Contribution to journal › Article

Abstract

We conducted a cross-sectional investigation to identify evidence of a potential modifying effect of chromosomally integrated human herpes virus 6 (ciHHV-6) on human immunodeficiency virus (HIV) disease progression and/or severity. ciHHV-6 was identified by detecting HHV-6 DNA in hair follicle specimens of 439 subjects. There was no statistically significant relationship between the presence of ciHHV-6 and HIV disease progression to acquired immunodeficiency syndrome. However, after adjusting for use of antiretroviral therapy, all subjects with ciHHV-6 had low severity HIV disease; these findings were not statistically significant. A multi-center study with a larger sample size will be needed to more precisely determine if there is an association between ciHHV-6 and low HIV disease severity.

Original language	English (US)
Article number	269
Journal	F1000Research
Volume	2
DOIs	https://doi.org/10.12688/f1000research.2-269.v2
Publication status	Published - Jan 1 2017

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ASJC Scopus subject areas

Biochemistry, Genetics and Molecular Biology(all)
Immunology and Microbiology(all)
Pharmacology, Toxicology and Pharmaceutics(all)

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Kainth, M. K., Fisher, S. G., Fernandez, D., Luque, A., Hall, C. B., Hoang, A. T., ... Caserta, M. T. (2017). Understanding the association between chromosomally integrated human herpesvirus 6 and HIV disease: A cross-sectional study. F1000Research, 2, [269]. https://doi.org/10.12688/f1000research.2-269.v2

Understanding the association between chromosomally integrated human herpesvirus 6 and HIV disease : A cross-sectional study. / Kainth, Mundeep K.; Fisher, Susan G.; Fernandez, Diana; Luque, Amneris; Hall, Caroline B.; Hoang, Anh Thi; Lashkari, Anisha; Peck, Alexandra; Hasan, Lubaba; Caserta, Mary T.

In: F1000Research, Vol. 2, 269, 01.01.2017.

Research output: Contribution to journal › Article

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10.12688/f1000research.2-269.v2