Understanding the association between chromosomally integrated human herpesvirus 6 and HIV disease: A cross-sectional study

Mundeep K. Kainth, Susan G. Fisher, Diana Fernandez, Amneris Luque, Caroline B. Hall, Anh Thi Hoang, Anisha Lashkari, Alexandra Peck, Lubaba Hasan, Mary T. Caserta

Research output: Contribution to journalArticle

Abstract

We conducted a cross-sectional investigation to identify evidence of a potential modifying effect of chromosomally integrated human herpes virus 6 (ciHHV-6) on human immunodeficiency virus (HIV) disease progression and/or severity. ciHHV-6 was identified by detecting HHV-6 DNA in hair follicle specimens of 439 subjects. There was no statistically significant relationship between the presence of ciHHV-6 and HIV disease progression to acquired immunodeficiency syndrome. However, after adjusting for use of antiretroviral therapy, all subjects with ciHHV-6 had low severity HIV disease; these findings were not statistically significant. A multi-center study with a larger sample size will be needed to more precisely determine if there is an association between ciHHV-6 and low HIV disease severity.

Original languageEnglish (US)
Article number2-269.v1
JournalF1000Research
Volume2
DOIs
StatePublished - Dec 9 2013

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Immunology and Microbiology(all)
  • Pharmacology, Toxicology and Pharmaceutics(all)

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    Kainth, M. K., Fisher, S. G., Fernandez, D., Luque, A., Hall, C. B., Hoang, A. T., Lashkari, A., Peck, A., Hasan, L., & Caserta, M. T. (2013). Understanding the association between chromosomally integrated human herpesvirus 6 and HIV disease: A cross-sectional study. F1000Research, 2, [2-269.v1]. https://doi.org/10.12688/f1000research.2-269.v1