Understanding the association between chromosomally integrated human herpesvirus 6 and HIV disease

A cross-sectional study

Mundeep K. Kainth, Susan G. Fisher, Diana Fernandez, Amneris Luque, Caroline B. Hall, Anh Thi Hoang, Anisha Lashkari, Alexandra Peck, Lubaba Hasan, Mary T. Caserta

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

We conducted a cross-sectional investigation to identify evidence of a potential modifying effect of chromosomally integrated human herpes virus 6 (ciHHV-6) on human immunodeficiency virus (HIV) disease progression and/or severity. ciHHV-6 was identified by detecting HHV-6 DNA in hair follicle specimens of 439 subjects. There was no statistically significant relationship between the presence of ciHHV-6 and HIV disease progression to acquired immunodeficiency syndrome. However, after adjusting for use of antiretroviral therapy, all subjects with ciHHV-6 had low severity HIV disease; these findings were not statistically significant. A multi-center study with a larger sample size will be needed to more precisely determine if there is an association between ciHHV-6 and low HIV disease severity.

Original languageEnglish (US)
Article number2-269.v1
JournalF1000Research
Volume2
DOIs
StatePublished - Dec 9 2013

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Human Herpesvirus 6
Virus Diseases
Viruses
Cross-Sectional Studies
HIV
Disease Progression
Hair Follicle
Sample Size
Acquired Immunodeficiency Syndrome
DNA

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Immunology and Microbiology(all)
  • Pharmacology, Toxicology and Pharmaceutics(all)

Cite this

Understanding the association between chromosomally integrated human herpesvirus 6 and HIV disease : A cross-sectional study. / Kainth, Mundeep K.; Fisher, Susan G.; Fernandez, Diana; Luque, Amneris; Hall, Caroline B.; Hoang, Anh Thi; Lashkari, Anisha; Peck, Alexandra; Hasan, Lubaba; Caserta, Mary T.

In: F1000Research, Vol. 2, 2-269.v1, 09.12.2013.

Research output: Contribution to journalArticle

Kainth, MK, Fisher, SG, Fernandez, D, Luque, A, Hall, CB, Hoang, AT, Lashkari, A, Peck, A, Hasan, L & Caserta, MT 2013, 'Understanding the association between chromosomally integrated human herpesvirus 6 and HIV disease: A cross-sectional study', F1000Research, vol. 2, 2-269.v1. https://doi.org/10.12688/f1000research.2-269.v1
Kainth, Mundeep K. ; Fisher, Susan G. ; Fernandez, Diana ; Luque, Amneris ; Hall, Caroline B. ; Hoang, Anh Thi ; Lashkari, Anisha ; Peck, Alexandra ; Hasan, Lubaba ; Caserta, Mary T. / Understanding the association between chromosomally integrated human herpesvirus 6 and HIV disease : A cross-sectional study. In: F1000Research. 2013 ; Vol. 2.
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