Understanding the association between chromosomally integrated human herpesvirus 6 and HIV disease: A cross-sectional study

Mundeep K. Kainth; Susan G. Fisher; Diana Fernandez; Amneris Luque; Caroline B. Hall; Anh Thi Hoang; Anisha Lashkari; Alexandra Peck; Lubaba Hasan; Mary T. Caserta

doi:10.12688/f1000research.2-269.v1

Understanding the association between chromosomally integrated human herpesvirus 6 and HIV disease: A cross-sectional study

Mundeep K. Kainth, Susan G. Fisher, Diana Fernandez, Amneris Luque, Caroline B. Hall, Anh Thi Hoang, Anisha Lashkari, Alexandra Peck, Lubaba Hasan, Mary T. Caserta

Research output: Contribution to journal › Article › peer-review

Abstract

We conducted a cross-sectional investigation to identify evidence of a potential modifying effect of chromosomally integrated human herpes virus 6 (ciHHV-6) on human immunodeficiency virus (HIV) disease progression and/or severity. ciHHV-6 was identified by detecting HHV-6 DNA in hair follicle specimens of 439 subjects. There was no statistically significant relationship between the presence of ciHHV-6 and HIV disease progression to acquired immunodeficiency syndrome. However, after adjusting for use of antiretroviral therapy, all subjects with ciHHV-6 had low severity HIV disease; these findings were not statistically significant. A multi-center study with a larger sample size will be needed to more precisely determine if there is an association between ciHHV-6 and low HIV disease severity.

Original language	English (US)
Article number	2-269.v1
Journal	F1000Research
Volume	2
DOIs	https://doi.org/10.12688/f1000research.2-269.v1
State	Published - Dec 9 2013

ASJC Scopus subject areas

General Biochemistry, Genetics and Molecular Biology
General Immunology and Microbiology
Pharmacology, Toxicology and Pharmaceutics(all)

Access to Document

10.12688/f1000research.2-269.v1

Cite this

@article{77376c4ea4974676bfe1957366db65fe,

title = "Understanding the association between chromosomally integrated human herpesvirus 6 and HIV disease: A cross-sectional study",

abstract = "We conducted a cross-sectional investigation to identify evidence of a potential modifying effect of chromosomally integrated human herpes virus 6 (ciHHV-6) on human immunodeficiency virus (HIV) disease progression and/or severity. ciHHV-6 was identified by detecting HHV-6 DNA in hair follicle specimens of 439 subjects. There was no statistically significant relationship between the presence of ciHHV-6 and HIV disease progression to acquired immunodeficiency syndrome. However, after adjusting for use of antiretroviral therapy, all subjects with ciHHV-6 had low severity HIV disease; these findings were not statistically significant. A multi-center study with a larger sample size will be needed to more precisely determine if there is an association between ciHHV-6 and low HIV disease severity.",

author = "Kainth, {Mundeep K.} and Fisher, {Susan G.} and Diana Fernandez and Amneris Luque and Hall, {Caroline B.} and Hoang, {Anh Thi} and Anisha Lashkari and Alexandra Peck and Lubaba Hasan and Caserta, {Mary T.}",

year = "2013",

month = dec,

day = "9",

doi = "10.12688/f1000research.2-269.v1",

language = "English (US)",

volume = "2",

journal = "F1000Research",

issn = "2046-1402",

publisher = "F1000 Research Ltd.",

}

TY - JOUR

T1 - Understanding the association between chromosomally integrated human herpesvirus 6 and HIV disease

T2 - A cross-sectional study

AU - Kainth, Mundeep K.

AU - Fisher, Susan G.

AU - Fernandez, Diana

AU - Luque, Amneris

AU - Hall, Caroline B.

AU - Hoang, Anh Thi

AU - Lashkari, Anisha

AU - Peck, Alexandra

AU - Hasan, Lubaba

AU - Caserta, Mary T.

PY - 2013/12/9

Y1 - 2013/12/9

N2 - We conducted a cross-sectional investigation to identify evidence of a potential modifying effect of chromosomally integrated human herpes virus 6 (ciHHV-6) on human immunodeficiency virus (HIV) disease progression and/or severity. ciHHV-6 was identified by detecting HHV-6 DNA in hair follicle specimens of 439 subjects. There was no statistically significant relationship between the presence of ciHHV-6 and HIV disease progression to acquired immunodeficiency syndrome. However, after adjusting for use of antiretroviral therapy, all subjects with ciHHV-6 had low severity HIV disease; these findings were not statistically significant. A multi-center study with a larger sample size will be needed to more precisely determine if there is an association between ciHHV-6 and low HIV disease severity.

AB - We conducted a cross-sectional investigation to identify evidence of a potential modifying effect of chromosomally integrated human herpes virus 6 (ciHHV-6) on human immunodeficiency virus (HIV) disease progression and/or severity. ciHHV-6 was identified by detecting HHV-6 DNA in hair follicle specimens of 439 subjects. There was no statistically significant relationship between the presence of ciHHV-6 and HIV disease progression to acquired immunodeficiency syndrome. However, after adjusting for use of antiretroviral therapy, all subjects with ciHHV-6 had low severity HIV disease; these findings were not statistically significant. A multi-center study with a larger sample size will be needed to more precisely determine if there is an association between ciHHV-6 and low HIV disease severity.

UR - http://www.scopus.com/inward/record.url?scp=84914813951&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84914813951&partnerID=8YFLogxK

U2 - 10.12688/f1000research.2-269.v1

DO - 10.12688/f1000research.2-269.v1

M3 - Article

SN - 2046-1402

VL - 2

JO - F1000Research

JF - F1000Research

M1 - 2-269.v1

ER -

Understanding the association between chromosomally integrated human herpesvirus 6 and HIV disease: A cross-sectional study

Abstract

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this