Understanding the Intersections between Metabolism and Cancer Biology

Matthew G. Vander Heiden, Ralph J. DeBerardinis

Research output: Contribution to journalReview articlepeer-review

567 Scopus citations

Abstract

Transformed cells adapt metabolism to support tumor initiation and progression. Specific metabolic activities can participate directly in the process of transformation or support the biological processes that enable tumor growth. Exploiting cancer metabolism for clinical benefit requires defining the pathways that are limiting for cancer progression and understanding the context specificity of metabolic preferences and liabilities in malignant cells. Progress toward answering these questions is providing new insight into cancer biology and can guide the more effective targeting of metabolism to help patients.

Original languageEnglish (US)
Pages (from-to)657-669
Number of pages13
JournalCell
Volume168
Issue number4
DOIs
StatePublished - Feb 9 2017

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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