Unraveling mechanisms of homeostatic synaptic plasticity

Karine Pozo, Yukiko Goda

Research output: Contribution to journalReview articlepeer-review

343 Scopus citations

Abstract

Homeostatic synaptic plasticity is a negative feedback mechanism that neurons use to offset excessive excitation or inhibition by adjusting their synaptic strengths. Recent findings reveal a complex web of signaling processes involved in this compensatory form of synaptic strength regulation, and in contrast to the popular view of homeostatic plasticity as a slow, global phenomenon, neurons may also rapidly tune the efficacy of individual synapses on demand. Here we review our current understanding of cellular and molecular mechanisms of homeostatic synaptic plasticity.

Original languageEnglish (US)
Pages (from-to)337-351
Number of pages15
JournalNeuron
Volume66
Issue number3
DOIs
StatePublished - May 2010

ASJC Scopus subject areas

  • Neuroscience(all)

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