Unravelling the pathogenesis of inflammatory bowel disease

R. J. Xavier, D. K. Podolsky

Research output: Contribution to journalArticle

2563 Scopus citations

Abstract

Recently, substantial advances in the understanding of the molecular pathogenesis of inflammatory bowel disease (IBD) have been made owing to three related lines of investigation. First, IBD has been found to be the most tractable of complex disorders for discovering susceptibility genes, and these have shown the importance of epithelial barrier function, and innate and adaptive immunity in disease pathogenesis. Second, efforts directed towards the identification of environmental factors implicate commensal bacteria (or their products), rather than conventional pathogens, as drivers of dysregulated immunity and IBD. Third, murine models, which exhibit many of the features of ulcerative colitis and seem to be bacteria-driven, have helped unravel the pathogenesis/mucosal immunopathology of IBD.

Original languageEnglish (US)
Pages (from-to)427-434
Number of pages8
JournalNature
Volume448
Issue number7152
DOIs
Publication statusPublished - Jul 26 2007

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