Unsolved mystery: The role of BRCA1 in DNA end-joining

Research output: Contribution to journalArticle

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Abstract

Heritable mutations in the tumor suppressor gene BRCA1 increase a woman's lifetime risk of developing breast and ovarian cancer. BRCA1's tumor suppressor function is directly linked to its myriad of functions in the cellular response to DNA double-strand breaks (DSBs). BRCA1 interacts with an extensive array of DNA damage responsive proteins and plays important roles in DSB repair, mediated by the homologous recombination pathway, and in the activation of cell cycle checkpoints. However, the role of BRCA1 in the other two DSB repair pathways, classical non-homologous end-joining (C-NHEJ) and alternative NHEJ (A-NHEJ), remains unclear. In this review, we will discuss the current literature on BRCA1's potential role(s) in modulating both C-NHEJ and A-NHEJ. We also present a model showing that BRCA1 contributes to genomic maintenance by promoting precise DNA repair across all cell cycle phases via the direct modulation of DNA end-joining.

Original languageEnglish (US)
Pages (from-to)i18-i24
JournalJournal of Radiation Research
Volume57
DOIs
StatePublished - Aug 1 2016

Fingerprint

Recombinational DNA Repair
Double-Stranded DNA Breaks
Cell Cycle Checkpoints
Tumor Suppressor Genes
DNA Repair
Ovarian Neoplasms
DNA Damage
Cell Cycle
deoxyribonucleic acid
Maintenance
strands
Breast Neoplasms
Mutation
DNA
Neoplasms
Proteins
tumor suppressor genes
suppressors
cycles
mutations

Keywords

  • BRCA1
  • breast cancer
  • DNA-PKcs
  • HR
  • Ku70/80
  • NHEJ

ASJC Scopus subject areas

  • Radiation
  • Radiology Nuclear Medicine and imaging
  • Health, Toxicology and Mutagenesis

Cite this

Unsolved mystery : The role of BRCA1 in DNA end-joining. / Saha, Janapriya; Davis, Anthony J.

In: Journal of Radiation Research, Vol. 57, 01.08.2016, p. i18-i24.

Research output: Contribution to journalArticle

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