Unstable angina and thrombolysis

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Unstable angina occurs in a heterogeneous population of patients. In the subset of patients with recent rest angina, both angiographic and angioscopic studies have suggested that coronary artery thrombus is often present and serves as a predictor of subsequent adverse clinical events, including recurrent angina, myocardial infarction, the need for urgent coronary revascularization, and death. Studies of thrombolytic therapy in small populations of patients with unstable angina suggest it may lyse coronary thrombus, raise the ischemic threshold, and possibly have a favorable influence on clinical outcome. Large multicenter trials of patients with unstable angina and non-Q-wave infarction have been designed to answer several questions: Will rt-PA produce improvement in angiographically determined coronary arterial stenoses? Is rt-PA superior to conventional therapy? Is there a need for routine angiography, followed by revascularization, in suitable patients? Until these questions are answered, the role of thrombolytic therapy in patients with unstable angina remains speculative.

Original languageEnglish (US)
JournalChest
Volume97
Issue number4 SUPPL.
StatePublished - 1990

Fingerprint

Unstable Angina
Thrombolytic Therapy
Thrombosis
Coronary Stenosis
Infarction
Population
Multicenter Studies
Coronary Vessels
Angiography
Myocardial Infarction

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine

Cite this

Unstable angina and thrombolysis. / Rutherford, J. D.

In: Chest, Vol. 97, No. 4 SUPPL., 1990.

Research output: Contribution to journalArticle

Rutherford, JD 1990, 'Unstable angina and thrombolysis', Chest, vol. 97, no. 4 SUPPL..
Rutherford, J. D. / Unstable angina and thrombolysis. In: Chest. 1990 ; Vol. 97, No. 4 SUPPL.
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