Unstirred water layers in intestine: Rate determinant of fatty acid absorption from micellar solutions

Frederick A. Wilson, Verney L. Sallee, John M. Dietschy

Research output: Contribution to journalArticle

103 Scopus citations

Abstract

Bile acid and fatty acid uptake from micellar solutions by intestinal cells fails to reflect the incremental free energy changes expected for permeation that is rate limited by cell membranes. However, altering the size of the diffusing particle or the thickness of the unstirred water layer does change uptake. These observations show that the unstirred water layer is rate limiting for intestinal absorption of lipids from micellar solutions.

Original languageEnglish (US)
Pages (from-to)1031-1033
Number of pages3
JournalScience
Volume174
Issue number4013
DOIs
StatePublished - Jan 1 1971

ASJC Scopus subject areas

  • General

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