Unusual case of Epstein-Barr virus DNA tissue positive: Blood negative in a patient with post-transplant lymphoproliferative disorder

Brian M. Levenson, Sabina A. Ali, Charles F. Timmons, Naveen Mittal, Alagar Muthukumar, Deborah A. Payne

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Detection of PTLD uses PCR to detect circulating EBV DNA in the blood or in situ hybridization to identify EBV DNA in tissue biopsies. EBV DNA was detected in the tissue section using both real-time PCR and in situ hybridization. We report an unusual presentation of PTLD with no detectable EBV DNA in the blood using EBER-1 and EBNA-1 PCR assays. This report suggests that the use of EBV-PCR for the early detection of PTLD in blood samples may not be 100% effective in detecting disease.

Original languageEnglish (US)
Pages (from-to)134-138
Number of pages5
JournalPediatric Transplantation
Volume13
Issue number1
DOIs
StatePublished - Feb 2009

Fingerprint

Lymphoproliferative Disorders
Human Herpesvirus 4
Transplants
DNA
Polymerase Chain Reaction
In Situ Hybridization
Real-Time Polymerase Chain Reaction
Biopsy

Keywords

  • Lymph node
  • Peripheral blood
  • PTLD

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Transplantation

Cite this

Unusual case of Epstein-Barr virus DNA tissue positive : Blood negative in a patient with post-transplant lymphoproliferative disorder. / Levenson, Brian M.; Ali, Sabina A.; Timmons, Charles F.; Mittal, Naveen; Muthukumar, Alagar; Payne, Deborah A.

In: Pediatric Transplantation, Vol. 13, No. 1, 02.2009, p. 134-138.

Research output: Contribution to journalArticle

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