Unusual presentations of BK virus infections in pediatric renal transplant recipients

Keri A. Drake, Lydia Najera, Robyn C. Reed, Priya S. Verghese

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

BKV has emerged as a significant pathogen in the field of transplantation, predominantly causing BKV nephropathy in renal transplant recipients and hemorrhagic cystitis in HSCT recipients. However, case reports describe more diverse complications, and we too present three unusual cases of BKV infections in pediatric renal transplant recipients. First, we describe a case of biopsy-proven renal damage secondary to BKV prior to the onset of viremia, demonstrating that BKV nephropathy can occur without preceding viremia. We also present two renal transplant recipients with persistent BK viruria, one with BKV-associated hemorrhagic cystitis and the other with microscopic hematuria. Therefore, we conclude that BKV manifestations may be more diverse than previously thought and suggest clinical utility in urine BKV qPCR testing in specific transplant recipients.

Original languageEnglish (US)
JournalPediatric Transplantation
Volume17
Issue number1
DOIs
StatePublished - Feb 1 2013

Fingerprint

BK Virus
Virus Diseases
Pediatrics
Kidney
Cystitis
Viremia
Hematuria
Transplantation
Urine
Biopsy
Transplant Recipients
Infection

Keywords

  • BK virus
  • BKV nephropathy
  • hemorrhagic cystitis
  • renal transplant

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Transplantation

Cite this

Unusual presentations of BK virus infections in pediatric renal transplant recipients. / Drake, Keri A.; Najera, Lydia; Reed, Robyn C.; Verghese, Priya S.

In: Pediatric Transplantation, Vol. 17, No. 1, 01.02.2013.

Research output: Contribution to journalArticle

Drake, Keri A. ; Najera, Lydia ; Reed, Robyn C. ; Verghese, Priya S. / Unusual presentations of BK virus infections in pediatric renal transplant recipients. In: Pediatric Transplantation. 2013 ; Vol. 17, No. 1.
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