Unveiling the mechanisms of cell-cell fusion

Research output: Contribution to journalReview article

256 Scopus citations

Abstract

Cell-cell fusion is fundamental to the development and physiology of multicellular organisms, but little is known of its mechanistic underpinnings. Recent studies have revealed that many proteins involved in cell-cell fusion are also required for seemingly unrelated cellular processes such as phagocytosis, cell migration, axon growth, and synaptogenesis. We review advances in understanding cell-cell fusion by contrasting it with virus-cell and intracellular vesicle fusion. We also consider how proteins involved in general aspects of membrane dynamics have been co-opted to control fusion of diverse cell types by coupling with specialized proteins involved in cell-cell recognition, adhesion, and signaling.

Original languageEnglish (US)
Pages (from-to)369-373
Number of pages5
JournalScience
Volume308
Issue number5720
DOIs
StatePublished - Apr 15 2005

ASJC Scopus subject areas

  • General

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