TY - JOUR
T1 - Upper tract urothelial carcinoma
T2 - Special considerations
AU - Hutchinson, Ryan Craig
AU - Haddad, Ahmed
AU - Sagalowsky, Arthur I
AU - Margulis, Vitaly
N1 - Publisher Copyright:
© 2016, Millennium Medical Publishing, Inc. All rights reserved.
PY - 2016/2
Y1 - 2016/2
N2 - Upper tract urothelial carcinoma (UTUC) is an uncommon disease with a prognosis worse than that of primary urothelial carcinoma (UC) of the bladder. Although surgery remains the mainstay of UTUC therapy, there is increasing enthusiasm for combined-modality approaches in both adjuvant and neoadjuvant settings. Nephron-sparing surgical strategies, including partial ureterectomy and purely endoscopic tumor resection, are also increasingly used. Through the development of multi-institutional consortiums, novel treatment algorithms can now be used to evaluate patients more efficiently and thoroughly than in the past. In addition, the genome of UC isolates has recently been sequenced and published, making it possible to identify molecular targets for future therapies. By reviewing the epidemiology, current management strategies, and areas of ongoing research in UTUC, we hope to provide a background of knowledge useful to clinicians managing patients with this challenging disease.
AB - Upper tract urothelial carcinoma (UTUC) is an uncommon disease with a prognosis worse than that of primary urothelial carcinoma (UC) of the bladder. Although surgery remains the mainstay of UTUC therapy, there is increasing enthusiasm for combined-modality approaches in both adjuvant and neoadjuvant settings. Nephron-sparing surgical strategies, including partial ureterectomy and purely endoscopic tumor resection, are also increasingly used. Through the development of multi-institutional consortiums, novel treatment algorithms can now be used to evaluate patients more efficiently and thoroughly than in the past. In addition, the genome of UC isolates has recently been sequenced and published, making it possible to identify molecular targets for future therapies. By reviewing the epidemiology, current management strategies, and areas of ongoing research in UTUC, we hope to provide a background of knowledge useful to clinicians managing patients with this challenging disease.
KW - Neoadjuvant chemotherapy
KW - Nephroureterectomy
KW - Partial ureterectomy
KW - Upper tract
KW - Ureteroscopy
KW - Urothelial carcinoma
UR - http://www.scopus.com/inward/record.url?scp=84975780386&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84975780386&partnerID=8YFLogxK
M3 - Article
C2 - 27057809
AN - SCOPUS:84975780386
SN - 1543-0790
VL - 14
SP - 101
EP - 109
JO - Clinical Advances in Hematology and Oncology
JF - Clinical Advances in Hematology and Oncology
IS - 2
ER -