Upregulation of myosin Va by snail is involved in cancer cell migration and metastasis

Linxiang Lan, Haibo Han, Huijing Zuo, Zhiguo Chen, Yantao Du, Wei Zhao, Jin Gu, Zhiqian Zhang

Research output: Contribution to journalArticle

46 Scopus citations

Abstract

Cell migration, which involves acto-myosin dynamics, cell adhesion, membrane trafficking and signal transduction, is a prerequisite for cancer cell metastasis. Here, we report that an actin-dependent molecular motor, unconventional myosin Va, is involved in this process and implicated in cancer metastasis. The mRNA expression of myosin Va is increased in a number of highly metastatic cancer cell lines and metastatic colorectal cancer tissues. Suppressing the expression of myosin Va by lentivirus-based RNA interference in highly metastatic cancer cells impeded their migration and metastasis capabilities both in vitro and in vivo. In addition, the levels of myosin Va in cancer cell lines are positively correlated with the expression of Snail, a transcriptional repressor that triggers epithelial-mesenchymal transition. Repression or overexpression of Snail in cancer cells caused reduced or elevated levels of myosin Va, respectively. Furthermore, Snail can bind to an E-box of the myosin Va promoter and induce its activity, which indicates that Snail might act as a transcriptional activator. These data demonstrate an essential role of myosin Va in cancer cell migration and metastasis, and suggest a novel target for Snail in its regulation of cancer progression.

Original languageEnglish (US)
Pages (from-to)53-64
Number of pages12
JournalInternational Journal of Cancer
Volume126
Issue number1
DOIs
StatePublished - Jan 1 2010
Externally publishedYes

Keywords

  • Metastasis
  • Migration
  • Myosin Va
  • Snail
  • Unconventional myosin

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

Fingerprint Dive into the research topics of 'Upregulation of myosin Va by snail is involved in cancer cell migration and metastasis'. Together they form a unique fingerprint.

  • Cite this