Ureidopenicillin therapy for acute antepartum pyelonephritis

Despite a frequency of 1% to 2%, few studies have been designed to evaluate treatment of women with antepartum pyelonephritis. We studied the clinical efficacy of two extended-spectrum ureidopenicillins for the treatment of 190 pregnant women with renal infection. Of these, 150 were treated with mezlocillin and 40 were given piperacillin. The clinical cure rate with either drug was 96%, and 78% responded within 48 hours and another 18% within 96 hours. These drugs were equally well tolerated and were safe and effective with no adverse maternal or fetal outcomes observed.