Urinary potassium excretion in the critically ill neonate

W. D. Engle, B. S. Arant

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

The possibility that negative potassium balance may occur in critically ill preterm neonates is suggested by factors such as the usual provision of minimal potassium intake, increased plasma aldosterone concentrations, increased prostaglandin synthesis, and the frequent use of diuretic agents. In order to assess the relationship between potassium balance and renal prostaglandins, nine infants with respiratory distress syndrome (mean birth weight 1,264 g, mean gestational age 30.6 weeks) were studied sequentially with timed-urine collections during the first four postnatal days and values were compared with those of 18 preterm infants without respiratory distress syndrome. Mean plasma potassium concentrations decreased significantly from 4.87 ± 0.19 mEq/L (mean ± SEM) on day 1 to 3.83 ± 0.18 mEq/L on day 4, (P < 0.05), and cumulative potassium balance was -4.07 ± 0.95 mEq/kg or 10% of estimated total body potassium. Urinary excretion of prostaglandin E2 on day 1 in infants with respiratory distress syndrome was significantly greater than in those without respiratory distress syndrome (22.0 ± 4.9 v 8.3 ± 1.6 ng/mg of creatinine) and varied directly with urinary potassium excretion (r = .66, P < .001). These studies suggest that consideration be given to the importance of providing sufficient potassium to prevent hypokalemia in the stressed preterm infant and that pharmacologic agents that alter prostaglandins or potassium excretion should be used with caution.

Original languageEnglish (US)
Pages (from-to)259-264
Number of pages6
JournalPediatrics
Volume74
Issue number2
StatePublished - 1984

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Critical Illness
Potassium
Newborn Infant
Newborn Respiratory Distress Syndrome
Prostaglandins
Premature Infants
Urine Specimen Collection
Hypokalemia
Aldosterone
Diuretics
Dinoprostone
Birth Weight
Gestational Age
Creatinine
Kidney

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

Cite this

Engle, W. D., & Arant, B. S. (1984). Urinary potassium excretion in the critically ill neonate. Pediatrics, 74(2), 259-264.

Urinary potassium excretion in the critically ill neonate. / Engle, W. D.; Arant, B. S.

In: Pediatrics, Vol. 74, No. 2, 1984, p. 259-264.

Research output: Contribution to journalArticle

Engle, WD & Arant, BS 1984, 'Urinary potassium excretion in the critically ill neonate', Pediatrics, vol. 74, no. 2, pp. 259-264.
Engle, W. D. ; Arant, B. S. / Urinary potassium excretion in the critically ill neonate. In: Pediatrics. 1984 ; Vol. 74, No. 2. pp. 259-264.
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