TY - JOUR
T1 - Urinary prostaglandin E2 as a biomarker for recurrent UTI in postmenopausal women
AU - Ebrahimzadeh, Tahmineh
AU - Kuprasertkul, Amy
AU - Neugent, Michael L.
AU - Lutz, Kevin C.
AU - Fuentes, Jorge L.
AU - Gadhvi, Jashkaran
AU - Khan, Fatima
AU - Zhang, Cong
AU - Sharon, Belle M.
AU - Orth, Kim
AU - Li, Qiwei
AU - Zimmern, Philippe E.
AU - de Nisco, Nicole J.
N1 - Funding Information:
This work was funded in part by the Felecia and John Cain Chair in Women’s Health in honor of PE Zimmern, the Welch Foundation grant AT-2030-20200401 (NJ De Nisco), the University of Texas System Rising STARs award (NJ De Nisco), the Welch Foundation grant I-1561 (K Orth), and Once Upon a Time Foundation (K Orth). K Orth is a Burroughs Welcome Investigator in Pathogenesis of Infectious Disease, a Beckman Young Investigator, and a W. W. Caruth, Jr., Biomedical Scholar and has an Earl A. Forsythe Chair in Biomedical Science.
Publisher Copyright:
© 2021 Rockefeller University Press. All rights reserved.
PY - 2021/7
Y1 - 2021/7
N2 - Urinary tract infection (UTI) is one of the most common adult bacterial infections and exhibits high recurrence rates, especially in postmenopausal women. Studies in mouse models suggest that cyclooxygenase-2 (COX-2)-mediated inflammation sensitizes the bladder to recurrent UTI (rUTI). However, COX-2-mediated inflammation has not been robustly studied in human rUTI. We used human cohorts to assess urothelial COX-2 production and evaluate its product, PGE2, as a biomarker for rUTI in postmenopausal women. We found that the percentage of COX-2-positive cells was elevated in inflamed versus uninflamed bladder regions. We analyzed the performance of urinary PGE2 as a biomarker for rUTI in a controlled cohort of 92 postmenopausal women and PGE2 consistently outperformed all other tested clinical variables as a predictor of rUTI status. Furthermore, time-to-relapse analysis indicated that the risk of rUTI relapse was 3.6 times higher in women with above median urinary PGE2 levels than with below median levels. Taken together, these data suggest that urinary PGE2 may be a clinically useful diagnostic and prognostic biomarker for rUTI in postmenopausal women.
AB - Urinary tract infection (UTI) is one of the most common adult bacterial infections and exhibits high recurrence rates, especially in postmenopausal women. Studies in mouse models suggest that cyclooxygenase-2 (COX-2)-mediated inflammation sensitizes the bladder to recurrent UTI (rUTI). However, COX-2-mediated inflammation has not been robustly studied in human rUTI. We used human cohorts to assess urothelial COX-2 production and evaluate its product, PGE2, as a biomarker for rUTI in postmenopausal women. We found that the percentage of COX-2-positive cells was elevated in inflamed versus uninflamed bladder regions. We analyzed the performance of urinary PGE2 as a biomarker for rUTI in a controlled cohort of 92 postmenopausal women and PGE2 consistently outperformed all other tested clinical variables as a predictor of rUTI status. Furthermore, time-to-relapse analysis indicated that the risk of rUTI relapse was 3.6 times higher in women with above median urinary PGE2 levels than with below median levels. Taken together, these data suggest that urinary PGE2 may be a clinically useful diagnostic and prognostic biomarker for rUTI in postmenopausal women.
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U2 - 10.26508/LSA.202000948
DO - 10.26508/LSA.202000948
M3 - Article
C2 - 33958485
AN - SCOPUS:85105482608
SN - 2575-1077
VL - 4
JO - Life Science Alliance
JF - Life Science Alliance
IS - 7
M1 - e202000948
ER -