Urinary retention in patients with BPH treated with finasteride or placebo over 4 years. Characterization of patients and ultimate outcomes

Claus G. Roehrborn, Reginald Bruskewitz, G. Curtis Nickel, Stanley Glickman, Clair Cox, Ronald Anderson, Stanley Kandzari, Richard Herlihy, George Kornitzer, B. Thomas Brown, H. Logan Holtgrewe, Alice Taylor, Daniel Wang, Joanne Waldstreicher

Research output: Contribution to journalArticle

81 Citations (Scopus)

Abstract

Objectives: Knowledge regarding the incidence and prevalence of acute urinary retention and the ultimate outcome is very limited. The purpose of the present analysis was to document the natural history and outcomes of acute urinary retention (AUR) further specified as being either precipitated or spontaneous, and to evaluate the potential benefit of finasteride therapy. Materials and Methods: Three thousand and forty men with moderate to severe symptoms of BPH and enlarged prostate glands by digital rectal examination were enrolled into the 4-year placebo-controlled PLESS trial and were evaluated for occurrences of AUR and BPH-related surgery. Men in the study were seen every 4 months; discontinued patients were followed up 6 months after discontinuation and again at the end of the 4-year trial. Complete 4-year data on outcomes (occurrence of AUR or BPH-related surgery) was available for 92% of the enrolled subjects in each treatment group. An endpoint committee, blinded to treatment group and center, reviewed and categorized all study-related documentation relating to retention and surgery. Results: Over the 4-year period, 99 of 1503 placebo-treated patients (6.6%) experienced one or more episodes of AUR in comparison with 42 or 1513 finasteride-treated patients (2.8%; p < 0.001). Approximately half of the episodes of retention were spontaneous and clearly BPH-related, while the other episodes were precipitated by another factor (PAUR). After spontaneous AUR, subsequent surgery was performed in 39 of 52 (75%) placebo-treated patients versus 8 of 20 (40%) finasteride-treated patients (p = 0.01). BPH-related surgery was less common in men who had a prior episode of PAUR (26% in the placebo group and 14% in the finasteride group). Conclusion: There is a continual risk of spontaneous and precipitated acute urinary retention in men with moderate to severe lower urinary tract symptoms and an enlarged prostate gland. Fewer patients who developed precipitated AUR than spontaneous AUR go on to need subsequent BPH-related surgery. Significantly fewer finasteride-than placebo-treated patients developed AUR, and among those men, fewer ultimately needed BPH-related surgery. Copyright (C) 2000 S. Karger AG, Basel.

Original languageEnglish (US)
Pages (from-to)528-536
Number of pages9
JournalEuropean Urology
Volume37
Issue number5
StatePublished - 2000

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Finasteride
Urinary Retention
Placebos
Prostate
Digital Rectal Examination
Lower Urinary Tract Symptoms
Natural History
Documentation
Therapeutics

Keywords

  • BPH
  • BPH surgery
  • Finasteride
  • Medical treatment
  • Natural history
  • Urinary retention

ASJC Scopus subject areas

  • Urology

Cite this

Roehrborn, C. G., Bruskewitz, R., Nickel, G. C., Glickman, S., Cox, C., Anderson, R., ... Waldstreicher, J. (2000). Urinary retention in patients with BPH treated with finasteride or placebo over 4 years. Characterization of patients and ultimate outcomes. European Urology, 37(5), 528-536.

Urinary retention in patients with BPH treated with finasteride or placebo over 4 years. Characterization of patients and ultimate outcomes. / Roehrborn, Claus G.; Bruskewitz, Reginald; Nickel, G. Curtis; Glickman, Stanley; Cox, Clair; Anderson, Ronald; Kandzari, Stanley; Herlihy, Richard; Kornitzer, George; Brown, B. Thomas; Holtgrewe, H. Logan; Taylor, Alice; Wang, Daniel; Waldstreicher, Joanne.

In: European Urology, Vol. 37, No. 5, 2000, p. 528-536.

Research output: Contribution to journalArticle

Roehrborn, CG, Bruskewitz, R, Nickel, GC, Glickman, S, Cox, C, Anderson, R, Kandzari, S, Herlihy, R, Kornitzer, G, Brown, BT, Holtgrewe, HL, Taylor, A, Wang, D & Waldstreicher, J 2000, 'Urinary retention in patients with BPH treated with finasteride or placebo over 4 years. Characterization of patients and ultimate outcomes', European Urology, vol. 37, no. 5, pp. 528-536.
Roehrborn, Claus G. ; Bruskewitz, Reginald ; Nickel, G. Curtis ; Glickman, Stanley ; Cox, Clair ; Anderson, Ronald ; Kandzari, Stanley ; Herlihy, Richard ; Kornitzer, George ; Brown, B. Thomas ; Holtgrewe, H. Logan ; Taylor, Alice ; Wang, Daniel ; Waldstreicher, Joanne. / Urinary retention in patients with BPH treated with finasteride or placebo over 4 years. Characterization of patients and ultimate outcomes. In: European Urology. 2000 ; Vol. 37, No. 5. pp. 528-536.
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abstract = "Objectives: Knowledge regarding the incidence and prevalence of acute urinary retention and the ultimate outcome is very limited. The purpose of the present analysis was to document the natural history and outcomes of acute urinary retention (AUR) further specified as being either precipitated or spontaneous, and to evaluate the potential benefit of finasteride therapy. Materials and Methods: Three thousand and forty men with moderate to severe symptoms of BPH and enlarged prostate glands by digital rectal examination were enrolled into the 4-year placebo-controlled PLESS trial and were evaluated for occurrences of AUR and BPH-related surgery. Men in the study were seen every 4 months; discontinued patients were followed up 6 months after discontinuation and again at the end of the 4-year trial. Complete 4-year data on outcomes (occurrence of AUR or BPH-related surgery) was available for 92{\%} of the enrolled subjects in each treatment group. An endpoint committee, blinded to treatment group and center, reviewed and categorized all study-related documentation relating to retention and surgery. Results: Over the 4-year period, 99 of 1503 placebo-treated patients (6.6{\%}) experienced one or more episodes of AUR in comparison with 42 or 1513 finasteride-treated patients (2.8{\%}; p < 0.001). Approximately half of the episodes of retention were spontaneous and clearly BPH-related, while the other episodes were precipitated by another factor (PAUR). After spontaneous AUR, subsequent surgery was performed in 39 of 52 (75{\%}) placebo-treated patients versus 8 of 20 (40{\%}) finasteride-treated patients (p = 0.01). BPH-related surgery was less common in men who had a prior episode of PAUR (26{\%} in the placebo group and 14{\%} in the finasteride group). Conclusion: There is a continual risk of spontaneous and precipitated acute urinary retention in men with moderate to severe lower urinary tract symptoms and an enlarged prostate gland. Fewer patients who developed precipitated AUR than spontaneous AUR go on to need subsequent BPH-related surgery. Significantly fewer finasteride-than placebo-treated patients developed AUR, and among those men, fewer ultimately needed BPH-related surgery. Copyright (C) 2000 S. Karger AG, Basel.",
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T1 - Urinary retention in patients with BPH treated with finasteride or placebo over 4 years. Characterization of patients and ultimate outcomes

AU - Roehrborn, Claus G.

AU - Bruskewitz, Reginald

AU - Nickel, G. Curtis

AU - Glickman, Stanley

AU - Cox, Clair

AU - Anderson, Ronald

AU - Kandzari, Stanley

AU - Herlihy, Richard

AU - Kornitzer, George

AU - Brown, B. Thomas

AU - Holtgrewe, H. Logan

AU - Taylor, Alice

AU - Wang, Daniel

AU - Waldstreicher, Joanne

PY - 2000

Y1 - 2000

N2 - Objectives: Knowledge regarding the incidence and prevalence of acute urinary retention and the ultimate outcome is very limited. The purpose of the present analysis was to document the natural history and outcomes of acute urinary retention (AUR) further specified as being either precipitated or spontaneous, and to evaluate the potential benefit of finasteride therapy. Materials and Methods: Three thousand and forty men with moderate to severe symptoms of BPH and enlarged prostate glands by digital rectal examination were enrolled into the 4-year placebo-controlled PLESS trial and were evaluated for occurrences of AUR and BPH-related surgery. Men in the study were seen every 4 months; discontinued patients were followed up 6 months after discontinuation and again at the end of the 4-year trial. Complete 4-year data on outcomes (occurrence of AUR or BPH-related surgery) was available for 92% of the enrolled subjects in each treatment group. An endpoint committee, blinded to treatment group and center, reviewed and categorized all study-related documentation relating to retention and surgery. Results: Over the 4-year period, 99 of 1503 placebo-treated patients (6.6%) experienced one or more episodes of AUR in comparison with 42 or 1513 finasteride-treated patients (2.8%; p < 0.001). Approximately half of the episodes of retention were spontaneous and clearly BPH-related, while the other episodes were precipitated by another factor (PAUR). After spontaneous AUR, subsequent surgery was performed in 39 of 52 (75%) placebo-treated patients versus 8 of 20 (40%) finasteride-treated patients (p = 0.01). BPH-related surgery was less common in men who had a prior episode of PAUR (26% in the placebo group and 14% in the finasteride group). Conclusion: There is a continual risk of spontaneous and precipitated acute urinary retention in men with moderate to severe lower urinary tract symptoms and an enlarged prostate gland. Fewer patients who developed precipitated AUR than spontaneous AUR go on to need subsequent BPH-related surgery. Significantly fewer finasteride-than placebo-treated patients developed AUR, and among those men, fewer ultimately needed BPH-related surgery. Copyright (C) 2000 S. Karger AG, Basel.

AB - Objectives: Knowledge regarding the incidence and prevalence of acute urinary retention and the ultimate outcome is very limited. The purpose of the present analysis was to document the natural history and outcomes of acute urinary retention (AUR) further specified as being either precipitated or spontaneous, and to evaluate the potential benefit of finasteride therapy. Materials and Methods: Three thousand and forty men with moderate to severe symptoms of BPH and enlarged prostate glands by digital rectal examination were enrolled into the 4-year placebo-controlled PLESS trial and were evaluated for occurrences of AUR and BPH-related surgery. Men in the study were seen every 4 months; discontinued patients were followed up 6 months after discontinuation and again at the end of the 4-year trial. Complete 4-year data on outcomes (occurrence of AUR or BPH-related surgery) was available for 92% of the enrolled subjects in each treatment group. An endpoint committee, blinded to treatment group and center, reviewed and categorized all study-related documentation relating to retention and surgery. Results: Over the 4-year period, 99 of 1503 placebo-treated patients (6.6%) experienced one or more episodes of AUR in comparison with 42 or 1513 finasteride-treated patients (2.8%; p < 0.001). Approximately half of the episodes of retention were spontaneous and clearly BPH-related, while the other episodes were precipitated by another factor (PAUR). After spontaneous AUR, subsequent surgery was performed in 39 of 52 (75%) placebo-treated patients versus 8 of 20 (40%) finasteride-treated patients (p = 0.01). BPH-related surgery was less common in men who had a prior episode of PAUR (26% in the placebo group and 14% in the finasteride group). Conclusion: There is a continual risk of spontaneous and precipitated acute urinary retention in men with moderate to severe lower urinary tract symptoms and an enlarged prostate gland. Fewer patients who developed precipitated AUR than spontaneous AUR go on to need subsequent BPH-related surgery. Significantly fewer finasteride-than placebo-treated patients developed AUR, and among those men, fewer ultimately needed BPH-related surgery. Copyright (C) 2000 S. Karger AG, Basel.

KW - BPH

KW - BPH surgery

KW - Finasteride

KW - Medical treatment

KW - Natural history

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