Urine vapor pattern for olivopontocerebellar degeneration

Roger N. Rosenberg, Arthur B. Robinson, David Partridge

Research output: Contribution to journalArticle

3 Scopus citations

Abstract

Autosomal dominant olivopontocerebellar degeneration was evaluated in a family numbering 414 living members. Urine samples were obtained from 5 affected and 5 unaffected not at-risk family members after 4 days on a synthetic diet. 159 urine vapor constituents were measured by gas-liquid and ion-exchange chromatography and a non-correlation index was calculated. 2 distinct populations of urine vapor patterns were identified which conformed to the normal and disease affected groups, thus a diagnostically useful pattern for this disease in this family has been demonstrated which will be helpful in genetic counselling and potential elimination of the disease.

Original languageEnglish (US)
Pages (from-to)365-368
Number of pages4
JournalClinical Biochemistry
Volume8
Issue number1-6
DOIs
StatePublished - Feb 1975

ASJC Scopus subject areas

  • Clinical Biochemistry

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