Urogenital abnormalities in genetic disease

A. Y. Barakat, M. G. Seikaly, V. M. Der Kaloustian

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Anomalies of the urinary tract rank third to fourth among congenital malformations and occur in about 10 per cent of the population. These anomalies generally are the result of interaction between environmental factors, such as maternal illness and exposure to noxious substances, and genetic factors, including monogenic mutations, chromosomal anomalies or multigenic interactions. It is estimated that approximately 15 per cent of all urogenital anomalies are owing to chromosomal aberrations, 31 per cent are multifactorial and 9 per cent are secondary to defined teratogenic factors during gestation. Frequently, urogenital anomalies are part of multiple congenital malformations involving other organ systems. The aim of this review is to list as completely as possible genetic disorders associated with different genitourinary anomalies.

Original languageEnglish (US)
Pages (from-to)778-785
Number of pages8
JournalJournal of Urology
Volume136
Issue number4
StatePublished - 1986

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Urogenital Abnormalities
Maternal Exposure
Inborn Genetic Diseases
Urinary Tract
Chromosome Aberrations
Pregnancy
Mutation
Population

ASJC Scopus subject areas

  • Urology

Cite this

Barakat, A. Y., Seikaly, M. G., & Der Kaloustian, V. M. (1986). Urogenital abnormalities in genetic disease. Journal of Urology, 136(4), 778-785.

Urogenital abnormalities in genetic disease. / Barakat, A. Y.; Seikaly, M. G.; Der Kaloustian, V. M.

In: Journal of Urology, Vol. 136, No. 4, 1986, p. 778-785.

Research output: Contribution to journalArticle

Barakat, AY, Seikaly, MG & Der Kaloustian, VM 1986, 'Urogenital abnormalities in genetic disease', Journal of Urology, vol. 136, no. 4, pp. 778-785.
Barakat AY, Seikaly MG, Der Kaloustian VM. Urogenital abnormalities in genetic disease. Journal of Urology. 1986;136(4):778-785.
Barakat, A. Y. ; Seikaly, M. G. ; Der Kaloustian, V. M. / Urogenital abnormalities in genetic disease. In: Journal of Urology. 1986 ; Vol. 136, No. 4. pp. 778-785.
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