Urological complications following use of recombinant human bone morphogenetic protein-2 in anterior lumbar interbody fusion Presented at the 2012 Joint Spine Section Meeting ; Clinical article

Daniel Lubelski, Kalil G. Abdullah, Amy S. Nowacki, Matthew D. Alvin, Michael P. Steinmetz, Srita Chakka, Yumeng Li, Nicholas Gajewski, Edward C. Benzel, Thomas E. Mroz

Research output: Contribution to journalArticle

9 Scopus citations


Object. The goal of this study was to compare the urological complications in patients after anterior lumbar interbody fusion (ALIF) with and without the use of recombinant human bone morphogenetic protein-2 (rhBMP-2). Methods. The authors retrospectively reviewed the medical records of all patients who underwent ALIF with and without rhBMP-2 between January 2002 and August 2010. Patient demographic, operative, and complication information was analyzed. Male patients who underwent ALIF between L-4 and S-1 were contacted to assess postoperative urological complications. Results. Of the 110 male patients who underwent ALIF and were included in this study, 59 were treated with rhBMP-2 and 51 did not receive rhBMP-2. The mean follow-up duration was 17.5 months for the rhBMP-2 group and 30.8 months for the control group. No difference was found regarding the total number of urological complications in the rhBMP-2 group versus the control group (22% vs 20%, respectively; p = 1.0) or for retrograde ejaculation specifically (8% vs 8%, respectively; p = 1.0). Conclusions. In this study, the use of rhBMP-2 with ALIF surgery was not associated with an increased incidence of urological complications and retrograde ejaculation when compared with control ALIF without rhBMP-2. Further prospective analyses that specifically look at these complications are warranted.

Original languageEnglish (US)
Pages (from-to)126-131
Number of pages6
JournalJournal of Neurosurgery: Spine
Issue number2
StatePublished - Feb 1 2013



  • Anterior lumbar interbody fusion
  • Bone morphogenetic protein
  • Functional neurosurgery
  • Recombinant human bone morphogenetic protein-2
  • Retrograde ejaculation
  • Urological complication

ASJC Scopus subject areas

  • Surgery
  • Neurology
  • Clinical Neurology

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