Use and interpretation of diagnostic vaccination in primary immunodeficiency: A working group report of the Basic and Clinical Immunology Interest Section of the American Academy of Allergy, Asthma & Immunology

Jordan S. Orange, Mark Ballow, E. Richard Stiehm, Zuhair K. Ballas, Javier Chinen, Maite De La Morena, Dinakantha Kumararatne, Terry O. Harville, Paul Hesterberg, Majed Koleilat, Sean McGhee, Elena E. Perez, Jason Raasch, Rebecca Scherzer, Harry Schroeder, Christine Seroogy, Aarnoud Huissoon, Ricardo U. Sorensen, Rohit Katial

Research output: Contribution to journalArticle

202 Scopus citations

Abstract

A major diagnostic intervention in the consideration of many patients suspected to have primary immunodeficiency diseases (PIDDs) is the application and interpretation of vaccination. Specifically, the antibody response to antigenic challenge with vaccines can provide substantive insight into the status of human immune function. There are numerous vaccines that are commonly used in healthy individuals, as well as others that are available for specialized applications. Both can potentially be used to facilitate consideration of PIDD. However, the application of vaccines and interpretation of antibody responses in this context are complex. These rely on consideration of numerous existing specific studies, interpolation of data from healthy populations, current diagnostic guidelines, and expert subspecialist practice. This document represents an attempt of a working group of the American Academy of Allergy, Asthma & Immunology to provide further guidance and synthesis in this use of vaccination for diagnostic purposes in consideration of PIDD, as well as to identify key areas for further research.

Original languageEnglish (US)
Pages (from-to)S1-S24
JournalJournal of Allergy and Clinical Immunology
Volume130
Issue number3 SUPPL.
DOIs
StatePublished - Sep 1 2012

    Fingerprint

Keywords

  • Vaccines
  • antibody deficiency
  • antigen challenge
  • common variable immunodeficiency
  • diagnosis
  • guideline
  • neoantigen
  • primary immunodeficiency
  • specific antibody deficiency

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

Cite this

Orange, J. S., Ballow, M., Stiehm, E. R., Ballas, Z. K., Chinen, J., De La Morena, M., Kumararatne, D., Harville, T. O., Hesterberg, P., Koleilat, M., McGhee, S., Perez, E. E., Raasch, J., Scherzer, R., Schroeder, H., Seroogy, C., Huissoon, A., Sorensen, R. U., & Katial, R. (2012). Use and interpretation of diagnostic vaccination in primary immunodeficiency: A working group report of the Basic and Clinical Immunology Interest Section of the American Academy of Allergy, Asthma & Immunology. Journal of Allergy and Clinical Immunology, 130(3 SUPPL.), S1-S24. https://doi.org/10.1016/j.jaci.2012.07.002