Use of 2-deoxy-2-[F-18]-fluoro-D-glucose positron emission tomography to monitor therapeutic response by rhabdomyosarcoma in children: Report of a retrospective case study

Fangyu Peng, Galina Rabkin, Otto Muzik

Research output: Contribution to journalArticle

21 Scopus citations

Abstract

PURPOSE: The purpose of this study was to study the use of 2-deoxy-2-[F-18]-fluoro-D-glucose positron emission tomography (F-18 FDG PET) for monitoring therapeutic response by rhabdomyosarcoma (RMSA) in children. PATIENTS AND METHODS: A retrospective case study was performed by searching a computer database for the patients with RMSA in whom F-18 FDG PET studies were performed pre- and posttreatment. The data of the PET studies from these patients were analyzed in conjunction with clinical treatment and other imaging studies to determine whether interval changes of F-18 FDG uptake by the RMSA reflect response of RMSA to treatment. RESULTS: Four patients with RMSA who received both pretreatment and posttreatment F-18 FDG PET studies were identified from the database and included in this study. A dramatic decrease of F-18 FDG uptake by the tumor was evident in the patients who had a favorable response to the therapy and prolonged remission of the disease. In contrast, persistent abnormal FDG uptake in one patient was associated with early relapse of the RMSA. CONCLUSIONS: F-18 FDG PET may be useful for monitoring therapeutic response by RMSA in children, which needs to be verified with a prospective study in a larger patient population.

Original languageEnglish (US)
Pages (from-to)394-397
Number of pages4
JournalClinical nuclear medicine
Volume31
Issue number7
DOIs
StatePublished - Jul 1 2006

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Keywords

  • 2-deoxy-2-[F-18]-fluoro-D-glucose
  • Pediatrics
  • Positron emission tomography
  • Rhabdomyosarcoma

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

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