Use of a thick-film capillary column for the analysis of organic acids in body fluids

Wolfram Meier-Augenstein, Georg F. Hoffmann, Bonnie Holmes, Jill L. Jones, William L. Nyhan, Larry Sweetman

Research output: Contribution to journalArticlepeer-review

Abstract

An improved method for the identification and quantification of organic acids in body fluids employing capillary gas chromatography-mass spectrometry has been developed. A thick-film capillary column, that combines the properties of a capillary column with those of a megabore column, has been successfully introduced into an existing method. Analysis over a concentration range from 1 μmol/l to 500 μmol/l body fluid is possible. This permits the assay of samples that are usually obtained in small volumes, e.g. cerebrospinal fluid.

Original languageEnglish (US)
Pages (from-to)127-135
Number of pages9
JournalJournal of Chromatography B: Biomedical Sciences and Applications
Volume615
Issue number1
DOIs
StatePublished - May 19 1993
Externally publishedYes

ASJC Scopus subject areas

  • Chemistry(all)

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