Use of clomiphene citrate in minimal stimulation in vitro fertilization negatively impacts endometrial thickness: An argument for a freeze-all approach

Beverly G. Reed, John L. Wu, Laurice Bou Nemer, Bruce R Carr, Orhan Bukulmez

Research output: Contribution to journalArticlepeer-review

5 Scopus citations

Abstract

Objective: Minimal stimulation IVF is a treatment option that uses clomiphene citrate (CC). We sought to evaluate how CC impacts endometrial thickness during minimal stimulation IVF cycles. Methods: We retrospectively analyzed a cohort of 230 cycles in 119 poor ovarian response patients. The IVF cycles were studied in three groups: 130 minimal stimulation cycles, 29 mild stimulation cycles, and 30 conventional high dose gonadotropin releasing hormone (GnRH) antagonist cycles. Thirty-three minimal stimulation IVF patients had 41 frozen embryo transfers (FET) which allowed us to study whether the CC effects were prolonged. Results: Endometrial thickness in the minimal stimulation group was significantly lower than the mild and conventional stimulation groups (7.3±2.2mm versus 11.4±3.3mm versus 12.9±3.8mm, respectively, p<0.0001). In patients who underwent minimal stimulation IVF followed by FET, significantly thicker endometrial thickness was achieved during their FET cycles as compared to their minimal stimulation cycles (7.95±2.1mm versus 10.3±1.8mm, p<0.0001). Conclusion: We concluded that endometrial thickness is impacted during minimal stimulation IVF cycles. Since negative effects on endometrial thickness are not observed in the patients’ subsequent FET cycle, a freeze-all approach is justified to mitigate adverse endometrial effects of CC in minimal stimulation IVF cycles.

Original languageEnglish (US)
Pages (from-to)355-362
Number of pages8
JournalJornal Brasileiro de Reproducao Assistida
Volume22
Issue number4
DOIs
StatePublished - 2018

Keywords

  • Advanced reproductive age
  • Clomiphene citrate
  • Diminished ovarian reserve
  • Endometrial stripe thickness
  • In vitro fertilization
  • Minimal stimulation

ASJC Scopus subject areas

  • Obstetrics and Gynecology

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