Use of computed tomography, magnetic resonance imaging, and localized 1H magnetic resonance spectroscopy in canavan's disease: A case Report

Harold G. Marks, Pilar A. Caro, Zhiyue Wang, John A. Detre, Andrew R. Bogdan, Debra A. Gusnard, Robert A. Zimmerman

Research output: Contribution to journalArticle

47 Scopus citations

Abstract

The neuroradiological evaluation of Canavan's disease in a 38‐month‐old girl is discussed. Computed tomography showed diffuse symmetrical low attenuation values of the subcortical and deep cerebral white matter. Magnetic resonance imaging demonstrated symmetrical diffuse low signal intensity of T1‐weighted images and high signal intensity on T2‐weighted images. With the use of 1H magnetic resonance spectroscopy, we were able to show elevated levels of N‐acetylaspartic acid in the occipital lobe of our patient. The in vivo measurement of N‐acetylaspartic acid in the brain by 1H magnetic resonance spectroscopy offers an additional noninvasive diagnostic test for establishing the diagnosis of Canavan's disease. With the increasing availability of magnetic resonance spectroscopy, clinicians may be able to confirm the diagnosis of Canavan's disease immediately after magnetic resonance imaging reveals the typical abnormalities of the white matter.

Original languageEnglish (US)
Pages (from-to)106-110
Number of pages5
JournalAnnals of Neurology
Volume30
Issue number1
DOIs
StatePublished - Jul 1991

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology

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