Use of contrast-enhanced ultrasound to study relationship between serum uric acid and renal microvascular perfusion in diabetic kidney disease

Ling Wang, Jia Fen Cheng, Li Ping Sun, Ya Xiang Song, Le Hang Guo, Jun Mei Xu, Tian Fu Wu, Chandra Mohan, Ai Peng, Hui Xiong Xu, Xin Ying Liu

Research output: Contribution to journalArticle

2 Scopus citations

Abstract

To investigate the relationship between uric acid and renal microvascular perfusion in diabetic kidney disease (DKD) using contrast-enhanced ultrasound (CEUS) method. Materials and Methods. 79 DKD patients and 26 healthy volunteers were enrolled. Renal function and urine protein markers were tested. DKD patients were subdivided into two groups including a normal serum uric acid (SUA) group and a high SUA group. Contrast-enhanced ultrasound (CEUS) was performed, and low acoustic power contrast-specific imaging was used for quantitative analysis. Results. Normal controls (NCs) had the highest levels of AUC, AUC1, and AUC2. Compared to the normal SUA DKD group, high SUA DKD patients had significantly higher IMAX, AUC, and AUC1 (P < 0.05). DKD patients with low urinary uric acid (UUA) excretion had significantly higher AUC2 compared to DKD patients with normal UUA (P < 0.05). Conclusion. Hyperuricemia in DKD patients was associated with a renal ultrasound image suggestive of microvascular hyperperfusion. The CEUS parameter AUC1 holds promise as an indicator for renal microvascular hyperperfusion, while AUC2 might be a useful indicator of declining glomerular filtration rate in DKD patients with decreased excretion of uric acid.

Original languageEnglish (US)
Article number732317
JournalBioMed Research International
Volume2015
DOIs
StatePublished - 2015

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Immunology and Microbiology(all)

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    Wang, L., Cheng, J. F., Sun, L. P., Song, Y. X., Guo, L. H., Xu, J. M., Wu, T. F., Mohan, C., Peng, A., Xu, H. X., & Liu, X. Y. (2015). Use of contrast-enhanced ultrasound to study relationship between serum uric acid and renal microvascular perfusion in diabetic kidney disease. BioMed Research International, 2015, [732317]. https://doi.org/10.1155/2015/732317