Use of diffusion and perfusion magnetic resonance imaging as a tool in acute stroke clinical trials

Steven Warach

Research output: Contribution to journalReview article

40 Scopus citations


In light of the slow progress in developing effective therapies for ischemic stroke, magnetic resonance imaging techniques have emerged as new tools in stroke clinical trials. Rapid imaging with magnetic resonance imaging, diffusion weighted imaging, perfusion imaging and angiography are being incorporated into phase II and phase III stroke trials to optimize patient selection based on positive imaging diagnosis of the ischemic pathophysiology specifically related to a drug's mechanism of action and as a direct biomarker of the effect of a treatment's effect on the brain.

Original languageEnglish (US)
Article number038
Pages (from-to)38-44
Number of pages7
JournalCurrent Controlled Trials in Cardiovascular Medicine
Issue number1
StatePublished - Mar 28 2001



  • Clinical trials
  • Diffusion
  • Magnetic resonance imaging
  • Perfusion
  • Stroke

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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