Use of proton pump inhibitors and subsequent risk of celiac disease

Benjamin Lebwohl, Stuart J. Spechler, Timothy C. Wang, Peter H R Green, Jonas F. Ludvigsson

Research output: Contribution to journalArticle

34 Scopus citations

Abstract

Background: The prevalence of celiac disease and the use of medications that inhibit acid secretion have both increased in recent decades. Aim: To explore the association between antisecretory medication exposure and subsequent development of celiac disease. Methods: In this population-based case control study, we identified patients with celiac disease diagnosed at all pathology departments in Sweden from July 2005 through February 2008. Patients were matched by age and gender with up to 5 controls. We identified prior prescriptions for proton pump inhibitors and histamine-2 receptor antagonists in all subjects. We used conditional logistic regression to measure the association between these prescriptions and the subsequent diagnosis of celiac disease. Results: Prior proton pump inhibitor prescription was strongly associated with celiac disease (OR 4.79; 95% CI 4.17-5.51). Patients prescribed both proton pump inhibitors and histamine-2 receptor antagonists had a higher risk of celiac disease (OR 5.96; 95% CI 3.58-9.91) than those prescribed proton pump inhibitors alone (OR 4.91; 95% CI 4.26-5.66) or histamine-2 receptor antagonists alone (OR 4.16; 95% CI 2.89-5.99). Conclusions: Exposure to antisecretory medications is associated with a subsequent diagnosis of celiac disease. The persistence of this association after excluding prescriptions in the year preceding the celiac disease diagnosis suggests a causal relationship.

Original languageEnglish (US)
Pages (from-to)36-40
Number of pages5
JournalDigestive and Liver Disease
Volume46
Issue number1
DOIs
StatePublished - Jan 1 2014

Keywords

  • Celiac disease
  • Proton pump inhibitors
  • Risk factors

ASJC Scopus subject areas

  • Hepatology
  • Gastroenterology

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