Use of Statins and Outcomes in Intracerebral Hemorrhage Patients

Fazeel M. Siddiqui, Carl D. Langefeld, Charles J. Moomaw, Mary E. Comeau, Padmini Sekar, Jonathan Rosand, Chelsea S. Kidwell, Sharyl Martini, Jennifer L. Osborne, Sonja Stutzman, Christiana Hall, Daniel Woo

Research output: Contribution to journalArticle

15 Scopus citations

Abstract

Background and Purpose-Statin use may be associated with improved outcome in intracerebral hemorrhage patients. However, the topic remains controversial. Our analysis examined the effect of prior, continued, or new statin use on intracerebral hemorrhage outcomes using the ERICH (Ethnic/Racial Variations of Intracerebral Hemorrhage) data set. Methods-We analyzed ERICH (a multicenter study designed to examine ethnic variations in the risk, presentation, and outcomes of intracerebral hemorrhage) to explore the association of statin use and hematoma growth, mortality, and 3-month disability. We computed subset analyses with respect to 3 statin categories (prior, continued, or new use). Results-Two thousand four hundred and fifty-seven enrolled cases (mean age, 62 years; 42% females) had complete data on mortality and 3-month disability (modified Rankin Scale). Among those, 1093 cases were on statins (prior, n=268; continued, n=423; new, n=402). Overall, statin use was associated with reduced mortality and disability without any effect on hematoma growth. This association was primarily driven by continued/new statin use. A multivariate analysis adjusted for age and major predictors for poor outcome showed that continued/new statins users had good outcomes compared with prior users. However, statins may have been continued/started more frequently among less severe patients. When a propensity score was developed based on factors that could influence a physician's decision in prescribing statins and used as a covariate, continued/new statin use was no longer a significant predictor of good outcome. Conclusions-Although statin use, especially continued/new use, was associated with improved intracerebral hemorrhage outcomes, this effect may merely reflect the physician's view of a patient's prognosis rather than a predictor of survival.

Original languageEnglish (US)
Pages (from-to)2098-2104
Number of pages7
JournalStroke
Volume48
Issue number8
DOIs
StatePublished - Aug 1 2017

Keywords

  • hematoma
  • hydroxymethylglutaryl-CoA reductase inhibitors
  • Intracerebral hemorrhage
  • mortality
  • outcome

ASJC Scopus subject areas

  • Clinical Neurology
  • Cardiology and Cardiovascular Medicine
  • Advanced and Specialized Nursing

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    Siddiqui, F. M., Langefeld, C. D., Moomaw, C. J., Comeau, M. E., Sekar, P., Rosand, J., Kidwell, C. S., Martini, S., Osborne, J. L., Stutzman, S., Hall, C., & Woo, D. (2017). Use of Statins and Outcomes in Intracerebral Hemorrhage Patients. Stroke, 48(8), 2098-2104. https://doi.org/10.1161/STROKEAHA.117.017358