Use of subatmospheric (VAC) therapy to improve bioengineered tissue grafting in diabetic foot wounds

Eric H. Espensen, Brent P. Nixon, Lawrence A. Lavery, David G. Armstrong

Research output: Contribution to journalReview article

28 Scopus citations


The use of bioengineered tissue and topical subatmospheric pressure therapy have both been widely accepted as adjunctive therapies for the treatment of noninfected, nonischemic diabetic foot wounds. This article describes a temporally overlapping method of care that includes a period of simultaneous application of bioengineered tissue (Apligraf, Novartis Pharmaceuticals Corp, East Hanover, New Jersey) and subatmospheric pressure therapy delivered through the VAC (Vacuum Assisted Closure) system (KCI, Inc, San Antonio, Texas). Future descriptive and analytic works may test the hypothesis that combined therapies used at different and often overlapping periods during the wound-healing cycle may be more effective than a single modality.

Original languageEnglish (US)
Pages (from-to)395-397
Number of pages3
JournalJournal of the American Podiatric Medical Association
Issue number7
StatePublished - Jul 2002


ASJC Scopus subject areas

  • Podiatry
  • Orthopedics and Sports Medicine

Cite this