Use of Topical Insulin to Treat Refractory Neurotrophic Corneal Ulcers

Angeline L. Wang, Eric Weinlander, Brandon M. Metcalf, Neal P. Barney, David M. Gamm, Sarah M. Nehls, Michael C. Struck

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Purpose: To report the clinical course of 6 patients with refractory neurotrophic corneal ulcers that were treated with topical insulin drops. Methods: Retrospective chart review of patients who had neurotrophic corneal ulcers or epithelial defects refractory to standard medical and surgical treatment. Insulin drops, prepared by mixing regular insulin in artificial tears with a polyethylene glycol and propylene glycol base at a concentration of 1 unit per milliliter, were prescribed 2 to 3 times daily. Results: Six patients, aged 2 to 73 years, developed neurotrophic corneal ulcers refractory to a range of medical and surgical treatments, including bandage contact lens, amniotic membrane grafting, and permanent tarsorrhaphy. Each patient was administered topical insulin drops with complete corneal reepithelialization within 7 to 25 days. Conclusions: Topical insulin may be a simple and effective treatment for refractory neurotrophic corneal ulcers. Further study is required to determine the clinical efficacy and side effect profile of insulin drops.

Original languageEnglish (US)
Pages (from-to)1426-1428
Number of pages3
JournalCornea
Volume36
Issue number11
DOIs
StatePublished - Nov 1 2017
Externally publishedYes

Fingerprint

Corneal Ulcer
Insulin
Propylene Glycol
Amnion
Contact Lenses
Bandages
Therapeutics

Keywords

  • corneal wound healing
  • neurotrophic corneal ulcers
  • topical insulin

ASJC Scopus subject areas

  • Ophthalmology

Cite this

Wang, A. L., Weinlander, E., Metcalf, B. M., Barney, N. P., Gamm, D. M., Nehls, S. M., & Struck, M. C. (2017). Use of Topical Insulin to Treat Refractory Neurotrophic Corneal Ulcers. Cornea, 36(11), 1426-1428. https://doi.org/10.1097/ICO.0000000000001297

Use of Topical Insulin to Treat Refractory Neurotrophic Corneal Ulcers. / Wang, Angeline L.; Weinlander, Eric; Metcalf, Brandon M.; Barney, Neal P.; Gamm, David M.; Nehls, Sarah M.; Struck, Michael C.

In: Cornea, Vol. 36, No. 11, 01.11.2017, p. 1426-1428.

Research output: Contribution to journalArticle

Wang, AL, Weinlander, E, Metcalf, BM, Barney, NP, Gamm, DM, Nehls, SM & Struck, MC 2017, 'Use of Topical Insulin to Treat Refractory Neurotrophic Corneal Ulcers', Cornea, vol. 36, no. 11, pp. 1426-1428. https://doi.org/10.1097/ICO.0000000000001297
Wang AL, Weinlander E, Metcalf BM, Barney NP, Gamm DM, Nehls SM et al. Use of Topical Insulin to Treat Refractory Neurotrophic Corneal Ulcers. Cornea. 2017 Nov 1;36(11):1426-1428. https://doi.org/10.1097/ICO.0000000000001297
Wang, Angeline L. ; Weinlander, Eric ; Metcalf, Brandon M. ; Barney, Neal P. ; Gamm, David M. ; Nehls, Sarah M. ; Struck, Michael C. / Use of Topical Insulin to Treat Refractory Neurotrophic Corneal Ulcers. In: Cornea. 2017 ; Vol. 36, No. 11. pp. 1426-1428.
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