Use of Topical Insulin to Treat Refractory Neurotrophic Corneal Ulcers

Angeline L. Wang, Eric Weinlander, Brandon M. Metcalf, Neal P. Barney, David M. Gamm, Sarah M. Nehls, Michael C. Struck

Research output: Contribution to journalArticle

5 Scopus citations

Abstract

Purpose: To report the clinical course of 6 patients with refractory neurotrophic corneal ulcers that were treated with topical insulin drops. Methods: Retrospective chart review of patients who had neurotrophic corneal ulcers or epithelial defects refractory to standard medical and surgical treatment. Insulin drops, prepared by mixing regular insulin in artificial tears with a polyethylene glycol and propylene glycol base at a concentration of 1 unit per milliliter, were prescribed 2 to 3 times daily. Results: Six patients, aged 2 to 73 years, developed neurotrophic corneal ulcers refractory to a range of medical and surgical treatments, including bandage contact lens, amniotic membrane grafting, and permanent tarsorrhaphy. Each patient was administered topical insulin drops with complete corneal reepithelialization within 7 to 25 days. Conclusions: Topical insulin may be a simple and effective treatment for refractory neurotrophic corneal ulcers. Further study is required to determine the clinical efficacy and side effect profile of insulin drops.

Original languageEnglish (US)
Pages (from-to)1426-1428
Number of pages3
JournalCornea
Volume36
Issue number11
DOIs
StatePublished - Nov 1 2017
Externally publishedYes

Keywords

  • corneal wound healing
  • neurotrophic corneal ulcers
  • topical insulin

ASJC Scopus subject areas

  • Ophthalmology

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    Wang, A. L., Weinlander, E., Metcalf, B. M., Barney, N. P., Gamm, D. M., Nehls, S. M., & Struck, M. C. (2017). Use of Topical Insulin to Treat Refractory Neurotrophic Corneal Ulcers. Cornea, 36(11), 1426-1428. https://doi.org/10.1097/ICO.0000000000001297