Use of zebrafish models for the analysis of human disease.

Hao Zhu, Leonard I. Zon

Research output: Contribution to journalArticle

5 Scopus citations

Abstract

The zebrafish has emerged as a powerful animal model for human diseases. While it has long informed us about the biology of early development, it has recently come into favor for the investigation of clinically relevant problems. Genes conserved from fish to humans can be rapidly analyzed using the zebrafish embryo in what is essentially a transparent in vivo assay. This unit describes methodologies including genetic screening, targeted knockdowns, ectopic overexpression, and transgenesis.

Original languageEnglish (US)
Pages (from-to)Unit 15.3
JournalCurrent protocols in human genetics / editorial board, Jonathan L. Haines ... [et al.]
VolumeChapter 15
StatePublished - Nov 2002

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ASJC Scopus subject areas

  • Genetics
  • Genetics(clinical)

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