Using metabolomics to assess myocardial metabolism and energetics in heart failure

Research output: Contribution to journalReview article

26 Scopus citations

Abstract

There is a long history of investigation into the metabolism of the failing heart. Congestive heart failure is marked both by severe disruptions in myocardial energy supply and an inability of the heart to efficiently uptake and oxidize fuels. Despite the many advancements in our understanding, there are still even more outstanding questions in the field. Metabolomics has the power to assist our understanding of the metabolic derangements which accompany myocardial dysfunction. Metabolomic investigations in animal models of heart failure have already highlighted several novel, potentially important pathways of substrate selection and toxicity. Metabolomic biomarker studies in humans, already successfully applied to other forms of cardiovascular disease, have the potential to improve diagnosis and patient care. This article is part of a Special Issue entitled "Focus on Cardiac Metabolism".

Original languageEnglish (US)
Pages (from-to)12-18
Number of pages7
JournalJournal of Molecular and Cellular Cardiology
Volume55
Issue number1
DOIs
StatePublished - Feb 1 2013

Keywords

  • Congestive heart failure
  • Energetics
  • Metabolomics

ASJC Scopus subject areas

  • Molecular Biology
  • Cardiology and Cardiovascular Medicine

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