Usual and Unusual Manifestations of Familial Hemophagocytic Lymphohistiocytosis and Langerhans Cell Histiocytosis

Craig Erker, Paul Harker-Murray, Julie An Talano

Research output: Contribution to journalReview articlepeer-review

4 Scopus citations

Abstract

Familial hemophagocytic lymphohistiocytosis (FHL) and Langerhans cell histiocytosis (LCH) are histiocytic diseases that occur most commonly in young children. Improvements in recognition and treatment have been substantial for both diseases in the past decade, although early and late morbidity continue to be major concerns. These two diagnoses behave differently, although the clinical spectra for both diseases are diverse and can lead to confusion and delays in diagnosis and treatment. This article focuses on the clinical and genetic spectrum of FHL as well as the clinical and treatment variations of LCH.

Original languageEnglish (US)
Pages (from-to)91-109
Number of pages19
JournalPediatric clinics of North America
Volume64
Issue number1
DOIs
StatePublished - Feb 1 2017

Keywords

  • Familial hemophagocytic lymphohistiocytosis (FHL)
  • Hemophagocytic lymphohistiocytosis (HLH)
  • Histiocytic disorders
  • Langerhans cell histiocytosis (LCH)

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

Fingerprint

Dive into the research topics of 'Usual and Unusual Manifestations of Familial Hemophagocytic Lymphohistiocytosis and Langerhans Cell Histiocytosis'. Together they form a unique fingerprint.

Cite this