Uterine metastasis from a heterologous metaplastic breast carcinoma simulating a primary uterine malignancy

Prasanna Sinkre, Sara Milchgrub, David S. Miller, Jorge Albores-Saavedra, Arif Hameed

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Objective. To describe the first distant metastasis of a heterologous metaplastic breast carcinoma in the uterus and discuss its differential diagnosis. Methods. Light microscopy, immunohistochemistry, and flow cytometry were used to evaluate the tumor. Results. A 58-year-old woman underwent mastectomy for metaplastic breast carcinoma confined to the breast. She presented 4 years later with vaginal bleeding. The endometrial curettage showed a poorly differentiated carcinoma. She underwent hysterectomy and bilateral salpingo-oophorectomy as well as pelvic and periaortic lymphadenectomy. Clinical and intraoperative findings favored a primary uterine malignancy. The uterus was markedly distorted with multiple gray- white, solid subserosal, and intramural tumor nodules. The tumor diffusely infiltrated the endometrium sparing benign endometrial glands. The tumor nodules were distributed full thickness of the myometrium. These nodules were composed of high-grade malignant epithelial cells with areas of chondroid metaplasia. Extrauterine microscopic tumor was present in left ovary, pelvic, and periaortic lymph nodes. The histologic features and estrogen/progesterone receptorS (ER/PR) as well as DNA ploidy analysis of the uterine tumor showed striking similarity with those of the primary metaplastic breast carcinoma. A diagnosis of metastatic metaplastic breast carcinoma in the uterus was rendered. Conclusion. A metastatic heterologous metaplastic breast carcinoma with cartilaginous metaplasia should be considered in the differential diagnosis of heterologous uterine malignant mixed mesodermal tumor (MMMT) and high-grade endometrioid carcinoma with rare foci of cartilage. (C) 2000 Academic Press.

Original languageEnglish (US)
Pages (from-to)216-218
Number of pages3
JournalGynecologic Oncology
Volume77
Issue number1
DOIs
StatePublished - Apr 2000

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Breast Neoplasms
Neoplasm Metastasis
Neoplasms
Uterus
Metaplasia
Differential Diagnosis
Malignant Mixed Tumor
Endometrioid Carcinoma
Curettage
Uterine Hemorrhage
Myometrium
Ploidies
Mastectomy
Ovariectomy
Progesterone Receptors
Endometrium
Lymph Node Excision
Hysterectomy
Estrogen Receptors
Cartilage

Keywords

  • Breast
  • Metaplastic carcinoma
  • Uterine metastasis

ASJC Scopus subject areas

  • Obstetrics and Gynecology
  • Oncology

Cite this

Uterine metastasis from a heterologous metaplastic breast carcinoma simulating a primary uterine malignancy. / Sinkre, Prasanna; Milchgrub, Sara; Miller, David S.; Albores-Saavedra, Jorge; Hameed, Arif.

In: Gynecologic Oncology, Vol. 77, No. 1, 04.2000, p. 216-218.

Research output: Contribution to journalArticle

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