Uteroplacental blood flow and estrogen production following dehydroisoandrosterone infusion

C. R. Rosenfeld, R. J. Worley, N. Gant

Research output: Contribution to journalArticle

10 Scopus citations

Abstract

The effects of systemic infusions of dehydroisoandrosterone on uterine blood flow and the plasma concentration of estrogen in ovine pregnancy were studied in 7 pregnant ewes at 52 to 128 days of gestation. Uterine blood flow increased 17.8% after a systemic infusion of dehydroisoandrosterone of 4.67 mg +/- 0.3. Maximum blood flows occurred 111 min +/- 5.8 after injection of dehydroisoandrosterone. The increase in flow (milliliter/minute) was greatest after 100 days of gestation. Plasma estrone concentrations increased from 67.9 pg/ml to 201 pg/ml, while estradiol rose from 42.9 pg/ml to 115 pg/ml (P<0.001). Estriol was not detected.

Original languageEnglish (US)
Pages (from-to)304-307
Number of pages4
JournalObstetrics and gynecology
Volume50
Issue number3
StatePublished - Aug 1977

ASJC Scopus subject areas

  • Obstetrics and Gynecology

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