The effects of systemic infusions of dehydroisoandrosterone on uterine blood flow and the plasma concentration of estrogen in ovine pregnancy were studied in 7 pregnant ewes at 52 to 128 days of gestation. Uterine blood flow increased 17.8% after a systemic infusion of dehydroisoandrosterone of 4.67 mg +/- 0.3. Maximum blood flows occurred 111 min +/- 5.8 after injection of dehydroisoandrosterone. The increase in flow (milliliter/minute) was greatest after 100 days of gestation. Plasma estrone concentrations increased from 67.9 pg/ml to 201 pg/ml, while estradiol rose from 42.9 pg/ml to 115 pg/ml (P<0.001). Estriol was not detected.
|Original language||English (US)|
|Number of pages||4|
|Journal||Obstetrics and gynecology|
|State||Published - Aug 1977|
ASJC Scopus subject areas
- Obstetrics and Gynecology