Uteroplacental blood flow and estrogen production following dehydroisoandrosterone infusion

C. R. Rosenfeld, R. J. Worley, N. Gant

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

The effects of systemic infusions of dehydroisoandrosterone on uterine blood flow and the plasma concentration of estrogen in ovine pregnancy were studied in 7 pregnant ewes at 52 to 128 days of gestation. Uterine blood flow increased 17.8% after a systemic infusion of dehydroisoandrosterone of 4.67 mg ± 0.3. Maximum blood flows occurred 111 min ± 5.8 after injection of dehydroisoandrosterone. The increase in flow (milliliter/minute) was greatest after 100 days of gestation. Plasma estrone concentrations increased from 67.9 pg/ml to 201 pg/ml, while estradiol rose from 42.9 pg/ml to 115 pg/ml (P<0.001). Estriol was not detected.

Original languageEnglish (US)
Pages (from-to)304-307
Number of pages4
JournalObstetrics and Gynecology
Volume50
Issue number3
StatePublished - 1977

Fingerprint

Dehydroepiandrosterone
Estrogens
Pregnancy
Estriol
Estrone
Estradiol
Sheep
Injections

ASJC Scopus subject areas

  • Obstetrics and Gynecology

Cite this

Uteroplacental blood flow and estrogen production following dehydroisoandrosterone infusion. / Rosenfeld, C. R.; Worley, R. J.; Gant, N.

In: Obstetrics and Gynecology, Vol. 50, No. 3, 1977, p. 304-307.

Research output: Contribution to journalArticle

@article{23c16dc50abf4d1c89d822f2285590cc,
title = "Uteroplacental blood flow and estrogen production following dehydroisoandrosterone infusion",
abstract = "The effects of systemic infusions of dehydroisoandrosterone on uterine blood flow and the plasma concentration of estrogen in ovine pregnancy were studied in 7 pregnant ewes at 52 to 128 days of gestation. Uterine blood flow increased 17.8{\%} after a systemic infusion of dehydroisoandrosterone of 4.67 mg ± 0.3. Maximum blood flows occurred 111 min ± 5.8 after injection of dehydroisoandrosterone. The increase in flow (milliliter/minute) was greatest after 100 days of gestation. Plasma estrone concentrations increased from 67.9 pg/ml to 201 pg/ml, while estradiol rose from 42.9 pg/ml to 115 pg/ml (P<0.001). Estriol was not detected.",
author = "Rosenfeld, {C. R.} and Worley, {R. J.} and N. Gant",
year = "1977",
language = "English (US)",
volume = "50",
pages = "304--307",
journal = "Obstetrics and Gynecology",
issn = "0029-7844",
publisher = "Lippincott Williams and Wilkins",
number = "3",

}

TY - JOUR

T1 - Uteroplacental blood flow and estrogen production following dehydroisoandrosterone infusion

AU - Rosenfeld, C. R.

AU - Worley, R. J.

AU - Gant, N.

PY - 1977

Y1 - 1977

N2 - The effects of systemic infusions of dehydroisoandrosterone on uterine blood flow and the plasma concentration of estrogen in ovine pregnancy were studied in 7 pregnant ewes at 52 to 128 days of gestation. Uterine blood flow increased 17.8% after a systemic infusion of dehydroisoandrosterone of 4.67 mg ± 0.3. Maximum blood flows occurred 111 min ± 5.8 after injection of dehydroisoandrosterone. The increase in flow (milliliter/minute) was greatest after 100 days of gestation. Plasma estrone concentrations increased from 67.9 pg/ml to 201 pg/ml, while estradiol rose from 42.9 pg/ml to 115 pg/ml (P<0.001). Estriol was not detected.

AB - The effects of systemic infusions of dehydroisoandrosterone on uterine blood flow and the plasma concentration of estrogen in ovine pregnancy were studied in 7 pregnant ewes at 52 to 128 days of gestation. Uterine blood flow increased 17.8% after a systemic infusion of dehydroisoandrosterone of 4.67 mg ± 0.3. Maximum blood flows occurred 111 min ± 5.8 after injection of dehydroisoandrosterone. The increase in flow (milliliter/minute) was greatest after 100 days of gestation. Plasma estrone concentrations increased from 67.9 pg/ml to 201 pg/ml, while estradiol rose from 42.9 pg/ml to 115 pg/ml (P<0.001). Estriol was not detected.

UR - http://www.scopus.com/inward/record.url?scp=0017717132&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0017717132&partnerID=8YFLogxK

M3 - Article

C2 - 142933

AN - SCOPUS:0017717132

VL - 50

SP - 304

EP - 307

JO - Obstetrics and Gynecology

JF - Obstetrics and Gynecology

SN - 0029-7844

IS - 3

ER -