Utility of Pathology Imagebase for standardisation of prostate cancer grading

Lars Egevad; Brett Delahunt; Daniel M. Berney; David G. Bostwick; John Cheville; Eva Comperat; Andrew J. Evans; Samson W. Fine; David J. Grignon; Peter A. Humphrey; Jonas Hörnblad; Kenneth A. Iczkowski; James G. Kench; Glen Kristiansen; Katia R.M. Leite; Cristina Magi-Galluzzi; Jesse K. McKenney; Jon Oxley; Chin Chen Pan; Hemamali Samaratunga; John R. Srigley; Hiroyuki Takahashi; Lawrence D. True; Toyonori Tsuzuki; Theo van der Kwast; Murali Varma; Ming Zhou; Mark Clements

doi:10.1111/his.13471

Utility of Pathology Imagebase for standardisation of prostate cancer grading

Lars Egevad, Brett Delahunt, Daniel M. Berney, David G. Bostwick, John Cheville, Eva Comperat, Andrew J. Evans, Samson W. Fine, David J. Grignon, Peter A. Humphrey, Jonas Hörnblad, Kenneth A. Iczkowski, James G. Kench, Glen Kristiansen, Katia R.M. Leite, Cristina Magi-Galluzzi, Jesse K. McKenney, Jon Oxley, Chin Chen Pan, Hemamali SamaratungaJohn R. Srigley, Hiroyuki Takahashi, Lawrence D. True, Toyonori Tsuzuki, Theo van der Kwast, Murali Varma, Ming Zhou, Mark Clements

Research output: Contribution to journal › Article › peer-review

36 Scopus citations

Abstract

Aims: Despite efforts to standardise grading of prostate cancer, even among experts there is still a considerable variation in grading practices. In this study we describe the use of Pathology Imagebase, a novel reference image library, for setting an international standard in prostate cancer grading. Methods and results: The International Society of Urological Pathology (ISUP) recently launched a reference image database supervised by experts. A panel of 24 international experts in prostate pathology reviewed independently microphotographs of 90 cases of prostate needle biopsies with cancer. A linear weighted kappa of 0.67 (95% confidence interval = 0.62–0.72) and consensus was reached in 50 cases. The interobserver weighted kappa varied from 0.48 to 0.89. The highest level of agreement was seen for Gleason score (GS) 3 + 3 = 6 (ISUP grade 1), while higher grades and particularly GS 4 + 3 = 7 (ISUP grade 3) showed considerable disagreement. Once a two-thirds majority was reached, images were moved automatically into a public database available for all ISUP members at www.isupweb.org. Non-members are able to access a limited number of cases. Conclusions: It is anticipated that the database will assist pathologists to calibrate their grading and, hence, decrease interobserver variability. It will also help to identify instances where definitions of grades need to be clarified.

Original language	English (US)
Pages (from-to)	8-18
Number of pages	11
Journal	Histopathology
Volume	73
Issue number	1
DOIs	https://doi.org/10.1111/his.13471
State	Published - Jul 2018

Keywords

International Society of Urological Pathology
database
grading
prostate
standardisation

ASJC Scopus subject areas

Pathology and Forensic Medicine
Histology

Access to Document

10.1111/his.13471

Cite this

Egevad, L., Delahunt, B., Berney, D. M., Bostwick, D. G., Cheville, J., Comperat, E., Evans, A. J., Fine, S. W., Grignon, D. J., Humphrey, P. A., Hörnblad, J., Iczkowski, K. A., Kench, J. G., Kristiansen, G., Leite, K. R. M., Magi-Galluzzi, C., McKenney, J. K., Oxley, J., Pan, C. C., ... Clements, M. (2018). Utility of Pathology Imagebase for standardisation of prostate cancer grading. Histopathology, 73(1), 8-18. https://doi.org/10.1111/his.13471

Egevad, L, Delahunt, B, Berney, DM, Bostwick, DG, Cheville, J, Comperat, E, Evans, AJ, Fine, SW, Grignon, DJ, Humphrey, PA, Hörnblad, J, Iczkowski, KA, Kench, JG, Kristiansen, G, Leite, KRM, Magi-Galluzzi, C, McKenney, JK, Oxley, J, Pan, CC, Samaratunga, H, Srigley, JR, Takahashi, H, True, LD, Tsuzuki, T, van der Kwast, T, Varma, M, Zhou, M & Clements, M 2018, 'Utility of Pathology Imagebase for standardisation of prostate cancer grading', Histopathology, vol. 73, no. 1, pp. 8-18. https://doi.org/10.1111/his.13471

@article{ddb43e65220047da917b7378c7085771,

title = "Utility of Pathology Imagebase for standardisation of prostate cancer grading",

abstract = "Aims: Despite efforts to standardise grading of prostate cancer, even among experts there is still a considerable variation in grading practices. In this study we describe the use of Pathology Imagebase, a novel reference image library, for setting an international standard in prostate cancer grading. Methods and results: The International Society of Urological Pathology (ISUP) recently launched a reference image database supervised by experts. A panel of 24 international experts in prostate pathology reviewed independently microphotographs of 90 cases of prostate needle biopsies with cancer. A linear weighted kappa of 0.67 (95% confidence interval = 0.62–0.72) and consensus was reached in 50 cases. The interobserver weighted kappa varied from 0.48 to 0.89. The highest level of agreement was seen for Gleason score (GS) 3 + 3 = 6 (ISUP grade 1), while higher grades and particularly GS 4 + 3 = 7 (ISUP grade 3) showed considerable disagreement. Once a two-thirds majority was reached, images were moved automatically into a public database available for all ISUP members at www.isupweb.org. Non-members are able to access a limited number of cases. Conclusions: It is anticipated that the database will assist pathologists to calibrate their grading and, hence, decrease interobserver variability. It will also help to identify instances where definitions of grades need to be clarified.",

keywords = "International Society of Urological Pathology, database, grading, prostate, standardisation",

author = "Lars Egevad and Brett Delahunt and Berney, {Daniel M.} and Bostwick, {David G.} and John Cheville and Eva Comperat and Evans, {Andrew J.} and Fine, {Samson W.} and Grignon, {David J.} and Humphrey, {Peter A.} and Jonas H{\"o}rnblad and Iczkowski, {Kenneth A.} and Kench, {James G.} and Glen Kristiansen and Leite, {Katia R.M.} and Cristina Magi-Galluzzi and McKenney, {Jesse K.} and Jon Oxley and Pan, {Chin Chen} and Hemamali Samaratunga and Srigley, {John R.} and Hiroyuki Takahashi and True, {Lawrence D.} and Toyonori Tsuzuki and {van der Kwast}, Theo and Murali Varma and Ming Zhou and Mark Clements",

note = "Publisher Copyright: {\textcopyright} 2018 John Wiley & Sons Ltd",

year = "2018",

month = jul,

doi = "10.1111/his.13471",

language = "English (US)",

volume = "73",

pages = "8--18",

journal = "Histopathology",

issn = "0309-0167",

publisher = "Wiley-Blackwell",

number = "1",

}

TY - JOUR

T1 - Utility of Pathology Imagebase for standardisation of prostate cancer grading

AU - Egevad, Lars

AU - Delahunt, Brett

AU - Berney, Daniel M.

AU - Bostwick, David G.

AU - Cheville, John

AU - Comperat, Eva

AU - Evans, Andrew J.

AU - Fine, Samson W.

AU - Grignon, David J.

AU - Humphrey, Peter A.

AU - Hörnblad, Jonas

AU - Iczkowski, Kenneth A.

AU - Kench, James G.

AU - Kristiansen, Glen

AU - Leite, Katia R.M.

AU - Magi-Galluzzi, Cristina

AU - McKenney, Jesse K.

AU - Oxley, Jon

AU - Pan, Chin Chen

AU - Samaratunga, Hemamali

AU - Srigley, John R.

AU - Takahashi, Hiroyuki

AU - True, Lawrence D.

AU - Tsuzuki, Toyonori

AU - van der Kwast, Theo

AU - Varma, Murali

AU - Zhou, Ming

AU - Clements, Mark

PY - 2018/7

Y1 - 2018/7

N2 - Aims: Despite efforts to standardise grading of prostate cancer, even among experts there is still a considerable variation in grading practices. In this study we describe the use of Pathology Imagebase, a novel reference image library, for setting an international standard in prostate cancer grading. Methods and results: The International Society of Urological Pathology (ISUP) recently launched a reference image database supervised by experts. A panel of 24 international experts in prostate pathology reviewed independently microphotographs of 90 cases of prostate needle biopsies with cancer. A linear weighted kappa of 0.67 (95% confidence interval = 0.62–0.72) and consensus was reached in 50 cases. The interobserver weighted kappa varied from 0.48 to 0.89. The highest level of agreement was seen for Gleason score (GS) 3 + 3 = 6 (ISUP grade 1), while higher grades and particularly GS 4 + 3 = 7 (ISUP grade 3) showed considerable disagreement. Once a two-thirds majority was reached, images were moved automatically into a public database available for all ISUP members at www.isupweb.org. Non-members are able to access a limited number of cases. Conclusions: It is anticipated that the database will assist pathologists to calibrate their grading and, hence, decrease interobserver variability. It will also help to identify instances where definitions of grades need to be clarified.

AB - Aims: Despite efforts to standardise grading of prostate cancer, even among experts there is still a considerable variation in grading practices. In this study we describe the use of Pathology Imagebase, a novel reference image library, for setting an international standard in prostate cancer grading. Methods and results: The International Society of Urological Pathology (ISUP) recently launched a reference image database supervised by experts. A panel of 24 international experts in prostate pathology reviewed independently microphotographs of 90 cases of prostate needle biopsies with cancer. A linear weighted kappa of 0.67 (95% confidence interval = 0.62–0.72) and consensus was reached in 50 cases. The interobserver weighted kappa varied from 0.48 to 0.89. The highest level of agreement was seen for Gleason score (GS) 3 + 3 = 6 (ISUP grade 1), while higher grades and particularly GS 4 + 3 = 7 (ISUP grade 3) showed considerable disagreement. Once a two-thirds majority was reached, images were moved automatically into a public database available for all ISUP members at www.isupweb.org. Non-members are able to access a limited number of cases. Conclusions: It is anticipated that the database will assist pathologists to calibrate their grading and, hence, decrease interobserver variability. It will also help to identify instances where definitions of grades need to be clarified.

KW - International Society of Urological Pathology

KW - database

KW - grading

KW - prostate

KW - standardisation

UR - http://www.scopus.com/inward/record.url?scp=85043289970&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85043289970&partnerID=8YFLogxK

U2 - 10.1111/his.13471

DO - 10.1111/his.13471

M3 - Article

C2 - 29359484

AN - SCOPUS:85043289970

SN - 0309-0167

VL - 73

SP - 8

EP - 18

JO - Histopathology

JF - Histopathology

IS - 1

ER -

Utility of Pathology Imagebase for standardisation of prostate cancer grading

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this