Vaccine-acquired rotavirus in infants with severe combined immunodeficiency

Niraj C. Patel; Paula M. Hertel; Mary K. Estes; Maite De La Morena; Ann M. Petru; Lenora M. Noroski; Paula A. Revell; I. Celine Hanson; Mary E. Paul; Howard M. Rosenblatt; Stuart L. Abramson

doi:10.1056/NEJMoa0904485

Vaccine-acquired rotavirus in infants with severe combined immunodeficiency

Niraj C. Patel, Paula M. Hertel, Mary K. Estes, Maite De La Morena, Ann M. Petru, Lenora M. Noroski, Paula A. Revell, I. Celine Hanson, Mary E. Paul, Howard M. Rosenblatt, Stuart L. Abramson

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166 Scopus citations

Abstract

Live pentavalent human-bovine reassortant rotavirus vaccine is recommended in the United States for routine immunization of infants. We describe three infants, two with failure to thrive, who had dehydration and diarrhea within 1 month after their first or second rotavirus immunization and subsequently received a diagnosis of severe combined immunodeficiency. Rotavirus was detected, by means of reverse-transcriptase-polymerase-chain-reaction (RT-PCR) assay, in stool specimens obtained from all three infants, and gene-sequence analysis revealed the presence of vaccine rotavirus. These infections raise concerns regarding the safety of rotavirus vaccine in severely immunocompromised patients.

Original language	English (US)
Pages (from-to)	314-319
Number of pages	6
Journal	New England Journal of Medicine
Volume	362
Issue number	4
DOIs	https://doi.org/10.1056/NEJMoa0904485
State	Published - Jan 28 2010

ASJC Scopus subject areas

Medicine(all)

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title = "Vaccine-acquired rotavirus in infants with severe combined immunodeficiency",

abstract = "Live pentavalent human-bovine reassortant rotavirus vaccine is recommended in the United States for routine immunization of infants. We describe three infants, two with failure to thrive, who had dehydration and diarrhea within 1 month after their first or second rotavirus immunization and subsequently received a diagnosis of severe combined immunodeficiency. Rotavirus was detected, by means of reverse-transcriptase-polymerase-chain-reaction (RT-PCR) assay, in stool specimens obtained from all three infants, and gene-sequence analysis revealed the presence of vaccine rotavirus. These infections raise concerns regarding the safety of rotavirus vaccine in severely immunocompromised patients.",

author = "Patel, {Niraj C.} and Hertel, {Paula M.} and Estes, {Mary K.} and {De La Morena}, Maite and Petru, {Ann M.} and Noroski, {Lenora M.} and Revell, {Paula A.} and Hanson, {I. Celine} and Paul, {Mary E.} and Rosenblatt, {Howard M.} and Abramson, {Stuart L.}",

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AU - Patel, Niraj C.

AU - Hertel, Paula M.

AU - Estes, Mary K.

AU - De La Morena, Maite

AU - Petru, Ann M.

AU - Noroski, Lenora M.

AU - Revell, Paula A.

AU - Hanson, I. Celine

AU - Paul, Mary E.

AU - Rosenblatt, Howard M.

AU - Abramson, Stuart L.

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AB - Live pentavalent human-bovine reassortant rotavirus vaccine is recommended in the United States for routine immunization of infants. We describe three infants, two with failure to thrive, who had dehydration and diarrhea within 1 month after their first or second rotavirus immunization and subsequently received a diagnosis of severe combined immunodeficiency. Rotavirus was detected, by means of reverse-transcriptase-polymerase-chain-reaction (RT-PCR) assay, in stool specimens obtained from all three infants, and gene-sequence analysis revealed the presence of vaccine rotavirus. These infections raise concerns regarding the safety of rotavirus vaccine in severely immunocompromised patients.

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Vaccine-acquired rotavirus in infants with severe combined immunodeficiency

Abstract

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