Vaccine-acquired rotavirus in infants with severe combined immunodeficiency

Niraj C. Patel, Paula M. Hertel, Mary K. Estes, Maite De La Morena, Ann M. Petru, Lenora M. Noroski, Paula A. Revell, I. Celine Hanson, Mary E. Paul, Howard M. Rosenblatt, Stuart L. Abramson

Research output: Contribution to journalArticle

136 Citations (Scopus)

Abstract

Live pentavalent human-bovine reassortant rotavirus vaccine is recommended in the United States for routine immunization of infants. We describe three infants, two with failure to thrive, who had dehydration and diarrhea within 1 month after their first or second rotavirus immunization and subsequently received a diagnosis of severe combined immunodeficiency. Rotavirus was detected, by means of reverse-transcriptase-polymerase-chain-reaction (RT-PCR) assay, in stool specimens obtained from all three infants, and gene-sequence analysis revealed the presence of vaccine rotavirus. These infections raise concerns regarding the safety of rotavirus vaccine in severely immunocompromised patients.

Original languageEnglish (US)
Pages (from-to)314-319
Number of pages6
JournalNew England Journal of Medicine
Volume362
Issue number4
DOIs
StatePublished - Jan 28 2010

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Rotavirus Vaccines
Severe Combined Immunodeficiency
Rotavirus
Immunization
Failure to Thrive
Immunocompromised Host
Reverse Transcriptase Polymerase Chain Reaction
Dehydration
Sequence Analysis
Diarrhea
Safety
Infection
Genes

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Patel, N. C., Hertel, P. M., Estes, M. K., De La Morena, M., Petru, A. M., Noroski, L. M., ... Abramson, S. L. (2010). Vaccine-acquired rotavirus in infants with severe combined immunodeficiency. New England Journal of Medicine, 362(4), 314-319. https://doi.org/10.1056/NEJMoa0904485

Vaccine-acquired rotavirus in infants with severe combined immunodeficiency. / Patel, Niraj C.; Hertel, Paula M.; Estes, Mary K.; De La Morena, Maite; Petru, Ann M.; Noroski, Lenora M.; Revell, Paula A.; Hanson, I. Celine; Paul, Mary E.; Rosenblatt, Howard M.; Abramson, Stuart L.

In: New England Journal of Medicine, Vol. 362, No. 4, 28.01.2010, p. 314-319.

Research output: Contribution to journalArticle

Patel, NC, Hertel, PM, Estes, MK, De La Morena, M, Petru, AM, Noroski, LM, Revell, PA, Hanson, IC, Paul, ME, Rosenblatt, HM & Abramson, SL 2010, 'Vaccine-acquired rotavirus in infants with severe combined immunodeficiency', New England Journal of Medicine, vol. 362, no. 4, pp. 314-319. https://doi.org/10.1056/NEJMoa0904485
Patel, Niraj C. ; Hertel, Paula M. ; Estes, Mary K. ; De La Morena, Maite ; Petru, Ann M. ; Noroski, Lenora M. ; Revell, Paula A. ; Hanson, I. Celine ; Paul, Mary E. ; Rosenblatt, Howard M. ; Abramson, Stuart L. / Vaccine-acquired rotavirus in infants with severe combined immunodeficiency. In: New England Journal of Medicine. 2010 ; Vol. 362, No. 4. pp. 314-319.
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