Vaginal fetal fibronectin measurements from 8 to 22 weeks' gestation and subsequent spontaneous preterm birth

Robert L. Goldenberg, Mark Klebanoff, J. Christopher Carey, Cora MacPherson, Kenneth J. Leveno, Atef H. Moawad, Baha Sibai, R. P. Heine, J. M. Ernest, Mitchell P. Dombrowski, Menachem Miodovnik, Ronald J. Wapner, Jay D. Iams, Oded Langer, Mary J. O'Sullivan, James M. Roberts

Research output: Contribution to journalArticle

42 Citations (Scopus)

Abstract

OBJECTIVE: We sought to determine the range of fetal fibronectin values in the vagina from 8 to 22 weeks' gestation, the factors associated with both low and high values, and whether high values are associated with gestational age at birth. STUDY DESIGN: Vaginal fetal fibronectin was quantitatively determined in a prospective cohort study of 13,360 women being evaluated for participation in the National Institute of Child Health and Human Development Maternal-Fetal Medicine Unit treatment trials for bacterial vaginosis and Trichomonas vaginalis. Fetal fibronectin values were correlated with gestational age at screening, race, the presence of bacterial vaginosis and Trichomonas vaginalis, and gestational age at delivery. RESULTS: Vaginal fetal fibronectin values at each gestational age ranged from unmeasurable to >1000 ng/mL, with median values always being <10 ng/mL. Fetal fibronectin values declined progressively with increasing gestational age at sampling. Bacterial vaginosis and black race were associated with higher values, whereas nulliparity was associated with lower values. High values after 13 weeks' gestation were associated with a 2- to 3-fold increased risk of subsequent spontaneous preterm birth overall and a 4-fold increased risk of very early preterm birth. CONCLUSION: Elevated vaginal fetal fibronectin levels from 13 to 22 weeks' gestation are associated with a significantly increased risk of spontaneous preterm birth.

Original languageEnglish (US)
Pages (from-to)469-475
Number of pages7
JournalAmerican Journal of Obstetrics and Gynecology
Volume183
Issue number2
StatePublished - 2000

Fingerprint

Premature Birth
Fibronectins
Gestational Age
Bacterial Vaginosis
Pregnancy
Trichomonas vaginalis
National Institute of Child Health and Human Development (U.S.)
Vagina
Parity
Cohort Studies
Mothers
Medicine
Parturition
Prospective Studies

Keywords

  • Bacterial vaginosis
  • Fetal fibronectin
  • Preterm birth
  • Trichomonas vaginalis

ASJC Scopus subject areas

  • Medicine(all)
  • Obstetrics and Gynecology

Cite this

Goldenberg, R. L., Klebanoff, M., Carey, J. C., MacPherson, C., Leveno, K. J., Moawad, A. H., ... Roberts, J. M. (2000). Vaginal fetal fibronectin measurements from 8 to 22 weeks' gestation and subsequent spontaneous preterm birth. American Journal of Obstetrics and Gynecology, 183(2), 469-475.

Vaginal fetal fibronectin measurements from 8 to 22 weeks' gestation and subsequent spontaneous preterm birth. / Goldenberg, Robert L.; Klebanoff, Mark; Carey, J. Christopher; MacPherson, Cora; Leveno, Kenneth J.; Moawad, Atef H.; Sibai, Baha; Heine, R. P.; Ernest, J. M.; Dombrowski, Mitchell P.; Miodovnik, Menachem; Wapner, Ronald J.; Iams, Jay D.; Langer, Oded; O'Sullivan, Mary J.; Roberts, James M.

In: American Journal of Obstetrics and Gynecology, Vol. 183, No. 2, 2000, p. 469-475.

Research output: Contribution to journalArticle

Goldenberg, RL, Klebanoff, M, Carey, JC, MacPherson, C, Leveno, KJ, Moawad, AH, Sibai, B, Heine, RP, Ernest, JM, Dombrowski, MP, Miodovnik, M, Wapner, RJ, Iams, JD, Langer, O, O'Sullivan, MJ & Roberts, JM 2000, 'Vaginal fetal fibronectin measurements from 8 to 22 weeks' gestation and subsequent spontaneous preterm birth', American Journal of Obstetrics and Gynecology, vol. 183, no. 2, pp. 469-475.
Goldenberg, Robert L. ; Klebanoff, Mark ; Carey, J. Christopher ; MacPherson, Cora ; Leveno, Kenneth J. ; Moawad, Atef H. ; Sibai, Baha ; Heine, R. P. ; Ernest, J. M. ; Dombrowski, Mitchell P. ; Miodovnik, Menachem ; Wapner, Ronald J. ; Iams, Jay D. ; Langer, Oded ; O'Sullivan, Mary J. ; Roberts, James M. / Vaginal fetal fibronectin measurements from 8 to 22 weeks' gestation and subsequent spontaneous preterm birth. In: American Journal of Obstetrics and Gynecology. 2000 ; Vol. 183, No. 2. pp. 469-475.
@article{8b12bd529714409482316888bfb813c5,
title = "Vaginal fetal fibronectin measurements from 8 to 22 weeks' gestation and subsequent spontaneous preterm birth",
abstract = "OBJECTIVE: We sought to determine the range of fetal fibronectin values in the vagina from 8 to 22 weeks' gestation, the factors associated with both low and high values, and whether high values are associated with gestational age at birth. STUDY DESIGN: Vaginal fetal fibronectin was quantitatively determined in a prospective cohort study of 13,360 women being evaluated for participation in the National Institute of Child Health and Human Development Maternal-Fetal Medicine Unit treatment trials for bacterial vaginosis and Trichomonas vaginalis. Fetal fibronectin values were correlated with gestational age at screening, race, the presence of bacterial vaginosis and Trichomonas vaginalis, and gestational age at delivery. RESULTS: Vaginal fetal fibronectin values at each gestational age ranged from unmeasurable to >1000 ng/mL, with median values always being <10 ng/mL. Fetal fibronectin values declined progressively with increasing gestational age at sampling. Bacterial vaginosis and black race were associated with higher values, whereas nulliparity was associated with lower values. High values after 13 weeks' gestation were associated with a 2- to 3-fold increased risk of subsequent spontaneous preterm birth overall and a 4-fold increased risk of very early preterm birth. CONCLUSION: Elevated vaginal fetal fibronectin levels from 13 to 22 weeks' gestation are associated with a significantly increased risk of spontaneous preterm birth.",
keywords = "Bacterial vaginosis, Fetal fibronectin, Preterm birth, Trichomonas vaginalis",
author = "Goldenberg, {Robert L.} and Mark Klebanoff and Carey, {J. Christopher} and Cora MacPherson and Leveno, {Kenneth J.} and Moawad, {Atef H.} and Baha Sibai and Heine, {R. P.} and Ernest, {J. M.} and Dombrowski, {Mitchell P.} and Menachem Miodovnik and Wapner, {Ronald J.} and Iams, {Jay D.} and Oded Langer and O'Sullivan, {Mary J.} and Roberts, {James M.}",
year = "2000",
language = "English (US)",
volume = "183",
pages = "469--475",
journal = "American Journal of Obstetrics and Gynecology",
issn = "0002-9378",
publisher = "Mosby Inc.",
number = "2",

}

TY - JOUR

T1 - Vaginal fetal fibronectin measurements from 8 to 22 weeks' gestation and subsequent spontaneous preterm birth

AU - Goldenberg, Robert L.

AU - Klebanoff, Mark

AU - Carey, J. Christopher

AU - MacPherson, Cora

AU - Leveno, Kenneth J.

AU - Moawad, Atef H.

AU - Sibai, Baha

AU - Heine, R. P.

AU - Ernest, J. M.

AU - Dombrowski, Mitchell P.

AU - Miodovnik, Menachem

AU - Wapner, Ronald J.

AU - Iams, Jay D.

AU - Langer, Oded

AU - O'Sullivan, Mary J.

AU - Roberts, James M.

PY - 2000

Y1 - 2000

N2 - OBJECTIVE: We sought to determine the range of fetal fibronectin values in the vagina from 8 to 22 weeks' gestation, the factors associated with both low and high values, and whether high values are associated with gestational age at birth. STUDY DESIGN: Vaginal fetal fibronectin was quantitatively determined in a prospective cohort study of 13,360 women being evaluated for participation in the National Institute of Child Health and Human Development Maternal-Fetal Medicine Unit treatment trials for bacterial vaginosis and Trichomonas vaginalis. Fetal fibronectin values were correlated with gestational age at screening, race, the presence of bacterial vaginosis and Trichomonas vaginalis, and gestational age at delivery. RESULTS: Vaginal fetal fibronectin values at each gestational age ranged from unmeasurable to >1000 ng/mL, with median values always being <10 ng/mL. Fetal fibronectin values declined progressively with increasing gestational age at sampling. Bacterial vaginosis and black race were associated with higher values, whereas nulliparity was associated with lower values. High values after 13 weeks' gestation were associated with a 2- to 3-fold increased risk of subsequent spontaneous preterm birth overall and a 4-fold increased risk of very early preterm birth. CONCLUSION: Elevated vaginal fetal fibronectin levels from 13 to 22 weeks' gestation are associated with a significantly increased risk of spontaneous preterm birth.

AB - OBJECTIVE: We sought to determine the range of fetal fibronectin values in the vagina from 8 to 22 weeks' gestation, the factors associated with both low and high values, and whether high values are associated with gestational age at birth. STUDY DESIGN: Vaginal fetal fibronectin was quantitatively determined in a prospective cohort study of 13,360 women being evaluated for participation in the National Institute of Child Health and Human Development Maternal-Fetal Medicine Unit treatment trials for bacterial vaginosis and Trichomonas vaginalis. Fetal fibronectin values were correlated with gestational age at screening, race, the presence of bacterial vaginosis and Trichomonas vaginalis, and gestational age at delivery. RESULTS: Vaginal fetal fibronectin values at each gestational age ranged from unmeasurable to >1000 ng/mL, with median values always being <10 ng/mL. Fetal fibronectin values declined progressively with increasing gestational age at sampling. Bacterial vaginosis and black race were associated with higher values, whereas nulliparity was associated with lower values. High values after 13 weeks' gestation were associated with a 2- to 3-fold increased risk of subsequent spontaneous preterm birth overall and a 4-fold increased risk of very early preterm birth. CONCLUSION: Elevated vaginal fetal fibronectin levels from 13 to 22 weeks' gestation are associated with a significantly increased risk of spontaneous preterm birth.

KW - Bacterial vaginosis

KW - Fetal fibronectin

KW - Preterm birth

KW - Trichomonas vaginalis

UR - http://www.scopus.com/inward/record.url?scp=0033848868&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0033848868&partnerID=8YFLogxK

M3 - Article

C2 - 10942489

AN - SCOPUS:0033848868

VL - 183

SP - 469

EP - 475

JO - American Journal of Obstetrics and Gynecology

JF - American Journal of Obstetrics and Gynecology

SN - 0002-9378

IS - 2

ER -