Validation of a research case definition of Gulf War illness in the 1991 US military population

Vincent G. Iannacchione, Jill A. Dever, Carla M. Bann, Kathleen A. Considine, Darryl Creel, Christopher P. Carson, Heather Best, Robert W. Haley

Research output: Contribution to journalArticlepeer-review

38 Scopus citations


Background: A case definition of Gulf War illness with 3 primary variants, previously developed by factor analysis of symptoms in a US Navy construction battalion and validated in clinic veterans, identified ill veterans with objective abnormalities of brain function. This study tests prestated hypotheses of its external validity. Methods: A stratified probability sample (n = 8,020), selected from a sampling frame of the 3.5 million Gulf War era US military veterans, completed a computer-assisted telephone interview survey. Application of the prior factor weights to the subjects' responses generated the case definition. Results: The structural equation model of the case definition fit both random halves of the population sample well (root mean-square error of approximation = 0.015). The overall case definition was 3.87 times (95% confidence interval, 2.61-5.74) more prevalent in the deployed than the deployable nondeployed veterans: 3.33 (1.10-10.10) for syndrome variant 1; 5.11 (2.43-10.75) for variant 2, and 4.25 (2.33-7.74) for variant 3. Functional status on SF-12 was greatly reduced (effect sizes, 1.0-2.0) in veterans meeting the overall and variant case definitions. Conclusions: The factor case definition applies to the full Gulf War veteran population and has good characteristics for research.

Original languageEnglish (US)
Pages (from-to)129-140
Number of pages12
Issue number2
StatePublished - Oct 2011


  • Case definition
  • Confirmatory factor analysis
  • Diagnostic criteria
  • Epidemiological methods
  • Health surveys
  • Persian Gulf syndrome
  • Validation studies

ASJC Scopus subject areas

  • Epidemiology
  • Clinical Neurology


Dive into the research topics of 'Validation of a research case definition of Gulf War illness in the 1991 US military population'. Together they form a unique fingerprint.

Cite this