Validation of diffuse correlation spectroscopy for muscle blood flow with concurrent arterial spin labeled perfusion MRI

Guoqiang Yu, Thomas F. Floyd, Turgut Durduran, Chao Zhou, Jiongjiong Wang, John A. Detre, Arjun G. Yodh

Research output: Contribution to journalArticle

131 Citations (Scopus)

Abstract

Calf blood flow was measured simultaneously in healthy human subjects (n = 7) during cuff inflation and deflation using near-infrared diffuse correlation spectroscopy (DCS) and arterial spin labeled perfusion MRI (ASL-MRI). The DCS and ASL-MRI data exhibited highly correlated absolute and relative dynamic flow responses in each individual (p < 0.001). Peak flow variations during hyperemia were also significantly correlated, though more for relative (p = 0.003) than absolute (p = 0.016) flow. Repeated measurement variation was less than 8% for both modalities. The results provide much needed quantitative blood flow validation of the diffuse optical correlation method in humans.

Original languageEnglish (US)
Pages (from-to)1064-1075
Number of pages12
JournalOptics Express
Volume15
Issue number3
DOIs
StatePublished - Feb 5 2007

Fingerprint

blood flow
muscles
cuffs
spectroscopy
calves

ASJC Scopus subject areas

  • Atomic and Molecular Physics, and Optics

Cite this

Validation of diffuse correlation spectroscopy for muscle blood flow with concurrent arterial spin labeled perfusion MRI. / Yu, Guoqiang; Floyd, Thomas F.; Durduran, Turgut; Zhou, Chao; Wang, Jiongjiong; Detre, John A.; Yodh, Arjun G.

In: Optics Express, Vol. 15, No. 3, 05.02.2007, p. 1064-1075.

Research output: Contribution to journalArticle

Yu, Guoqiang ; Floyd, Thomas F. ; Durduran, Turgut ; Zhou, Chao ; Wang, Jiongjiong ; Detre, John A. ; Yodh, Arjun G. / Validation of diffuse correlation spectroscopy for muscle blood flow with concurrent arterial spin labeled perfusion MRI. In: Optics Express. 2007 ; Vol. 15, No. 3. pp. 1064-1075.
@article{050be6c8a2424c2da96f11672bb13796,
title = "Validation of diffuse correlation spectroscopy for muscle blood flow with concurrent arterial spin labeled perfusion MRI",
abstract = "Calf blood flow was measured simultaneously in healthy human subjects (n = 7) during cuff inflation and deflation using near-infrared diffuse correlation spectroscopy (DCS) and arterial spin labeled perfusion MRI (ASL-MRI). The DCS and ASL-MRI data exhibited highly correlated absolute and relative dynamic flow responses in each individual (p < 0.001). Peak flow variations during hyperemia were also significantly correlated, though more for relative (p = 0.003) than absolute (p = 0.016) flow. Repeated measurement variation was less than 8{\%} for both modalities. The results provide much needed quantitative blood flow validation of the diffuse optical correlation method in humans.",
author = "Guoqiang Yu and Floyd, {Thomas F.} and Turgut Durduran and Chao Zhou and Jiongjiong Wang and Detre, {John A.} and Yodh, {Arjun G.}",
year = "2007",
month = "2",
day = "5",
doi = "10.1364/OE.15.001064",
language = "English (US)",
volume = "15",
pages = "1064--1075",
journal = "Optics Express",
issn = "1094-4087",
publisher = "The Optical Society",
number = "3",

}

TY - JOUR

T1 - Validation of diffuse correlation spectroscopy for muscle blood flow with concurrent arterial spin labeled perfusion MRI

AU - Yu, Guoqiang

AU - Floyd, Thomas F.

AU - Durduran, Turgut

AU - Zhou, Chao

AU - Wang, Jiongjiong

AU - Detre, John A.

AU - Yodh, Arjun G.

PY - 2007/2/5

Y1 - 2007/2/5

N2 - Calf blood flow was measured simultaneously in healthy human subjects (n = 7) during cuff inflation and deflation using near-infrared diffuse correlation spectroscopy (DCS) and arterial spin labeled perfusion MRI (ASL-MRI). The DCS and ASL-MRI data exhibited highly correlated absolute and relative dynamic flow responses in each individual (p < 0.001). Peak flow variations during hyperemia were also significantly correlated, though more for relative (p = 0.003) than absolute (p = 0.016) flow. Repeated measurement variation was less than 8% for both modalities. The results provide much needed quantitative blood flow validation of the diffuse optical correlation method in humans.

AB - Calf blood flow was measured simultaneously in healthy human subjects (n = 7) during cuff inflation and deflation using near-infrared diffuse correlation spectroscopy (DCS) and arterial spin labeled perfusion MRI (ASL-MRI). The DCS and ASL-MRI data exhibited highly correlated absolute and relative dynamic flow responses in each individual (p < 0.001). Peak flow variations during hyperemia were also significantly correlated, though more for relative (p = 0.003) than absolute (p = 0.016) flow. Repeated measurement variation was less than 8% for both modalities. The results provide much needed quantitative blood flow validation of the diffuse optical correlation method in humans.

UR - http://www.scopus.com/inward/record.url?scp=33846893670&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=33846893670&partnerID=8YFLogxK

U2 - 10.1364/OE.15.001064

DO - 10.1364/OE.15.001064

M3 - Article

C2 - 19532334

AN - SCOPUS:33846893670

VL - 15

SP - 1064

EP - 1075

JO - Optics Express

JF - Optics Express

SN - 1094-4087

IS - 3

ER -