Validation of diffuse correlation spectroscopy for muscle blood flow with concurrent arterial spin labeled perfusion MRI

Guoqiang Yu, Thomas F. Floyd, Turgut Durduran, Chao Zhou, Jiongjiong Wang, John A. Detre, Arjun G. Yodh

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136 Scopus citations


Calf blood flow was measured simultaneously in healthy human subjects (n = 7) during cuff inflation and deflation using near-infrared diffuse correlation spectroscopy (DCS) and arterial spin labeled perfusion MRI (ASL-MRI). The DCS and ASL-MRI data exhibited highly correlated absolute and relative dynamic flow responses in each individual (p < 0.001). Peak flow variations during hyperemia were also significantly correlated, though more for relative (p = 0.003) than absolute (p = 0.016) flow. Repeated measurement variation was less than 8% for both modalities. The results provide much needed quantitative blood flow validation of the diffuse optical correlation method in humans.

Original languageEnglish (US)
Pages (from-to)1064-1075
Number of pages12
JournalOptics Express
Issue number3
Publication statusPublished - Feb 5 2007


ASJC Scopus subject areas

  • Atomic and Molecular Physics, and Optics

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