TY - JOUR
T1 - Validation of Pediatric Self-Report Patient-Reported Outcomes Measurement Information System (PROMIS) Measures in Different Stages of Legg-Calvé-Perthes Disease
AU - from International Perthes Study Group
AU - Matsumoto, Hiroko
AU - Hyman, Joshua E.
AU - Shah, Hitesh H.
AU - Sankar, Wudbhav N.
AU - Laine, Jennifer C.
AU - Mehlman, Charles T.
AU - Schrader, Tim
AU - Kelly, Derek M.
AU - Rosenfeld, Scott B.
AU - Janicki, Joseph A.
AU - Thacker, Mihir M.
AU - Trupia, Evan
AU - McGuire, Molly F.
AU - Kim, Harry K.W.
N1 - Funding Information:
Supported by a grant from the Pediatric Orthopaedic Society of North America. Meetings to discuss this study were supported by the International Perthes Study Group and the Texas Scottish Rite Hospital for Children.
Publisher Copyright:
© 2020 Lippincott Williams and Wilkins. All rights reserved.
PY - 2020
Y1 - 2020
N2 - Objectives:Patient-reported outcomes (PRO) assessing health-related quality of life (HRQoL) are important outcome measures, especially in Legg-Calvé-Perthes disease (LCPD) where symptoms (pain and limping), activity restrictions, and treatments vary depending on the stage of the disease. The purpose of this study was to investigate the validity of the Patient-reported Outcomes Measurement Information System (PROMIS) for measuring HRQoL of patients with LCPD in various stages of the disease.Methods:This is a multicenter validity study. Patients with LCPD between 4 and 18 years old were included and classified into modified Waldenström stages of disease: Early (1 or 2A), Late (2B or 3), or Healed (4). Seven PROMIS domains were collected, including Pain Interference, Fatigue, Mobility, Depression, Anger, Anxiety, and Peer Relationships. Convergent, discriminant, and known group validity was determined.Results:A total of 190 patients were included (mean age: 10.4±3.1 y). All 7 domains showed the worst scores in patients in the Early stage (known group validity). Within each domain, all domains positively correlated to each other (convergent validity). Patients who reported more anxiety, depression, and anger were associated with decreased mobility and increased fatigue and pain. Peer relationships had no to weak associations with other domains (discriminant validity).Conclusions:PROMIS has construct validity in measuring the HRQoL of patients in different stages of LCPD, suggesting that PROMIS has potential to serve as a patient-reported outcome tool for this population.Level of Evidence:Diagnostic level III study.
AB - Objectives:Patient-reported outcomes (PRO) assessing health-related quality of life (HRQoL) are important outcome measures, especially in Legg-Calvé-Perthes disease (LCPD) where symptoms (pain and limping), activity restrictions, and treatments vary depending on the stage of the disease. The purpose of this study was to investigate the validity of the Patient-reported Outcomes Measurement Information System (PROMIS) for measuring HRQoL of patients with LCPD in various stages of the disease.Methods:This is a multicenter validity study. Patients with LCPD between 4 and 18 years old were included and classified into modified Waldenström stages of disease: Early (1 or 2A), Late (2B or 3), or Healed (4). Seven PROMIS domains were collected, including Pain Interference, Fatigue, Mobility, Depression, Anger, Anxiety, and Peer Relationships. Convergent, discriminant, and known group validity was determined.Results:A total of 190 patients were included (mean age: 10.4±3.1 y). All 7 domains showed the worst scores in patients in the Early stage (known group validity). Within each domain, all domains positively correlated to each other (convergent validity). Patients who reported more anxiety, depression, and anger were associated with decreased mobility and increased fatigue and pain. Peer relationships had no to weak associations with other domains (discriminant validity).Conclusions:PROMIS has construct validity in measuring the HRQoL of patients in different stages of LCPD, suggesting that PROMIS has potential to serve as a patient-reported outcome tool for this population.Level of Evidence:Diagnostic level III study.
KW - Legg-Calvé-Perthes disease
KW - health-related quality of life
KW - patient-reported outcome measures
KW - patient-reported outcomes measurement information system (PROMIS)
KW - reproducibility of results
UR - http://www.scopus.com/inward/record.url?scp=85083531206&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85083531206&partnerID=8YFLogxK
U2 - 10.1097/BPO.0000000000001423
DO - 10.1097/BPO.0000000000001423
M3 - Article
C2 - 31318732
AN - SCOPUS:85083531206
SN - 0271-6798
VL - 40
SP - 235
EP - 240
JO - Journal of Pediatric Orthopaedics
JF - Journal of Pediatric Orthopaedics
IS - 5
ER -