Validity of electronically monitored medication adherence and conventional adherence measures in schizophrenia

Matthew J. Byerly, Ann Thompson, Thomas Carmody, Rhiannon Bugno, Thomas Erwin, Michael Kashner, A. John Rush

Research output: Contribution to journalArticle

86 Citations (Scopus)

Abstract

Objective: This study evaluated the validity of prescriber, patient, and research assistant ratings of adherence to prescribed oral antipsychotic medication among outpatients with schizophrenia or schizoaffective disorder in comparison with electronic monitoring. Methods: Adult outpatients with schizophrenia (N=35) or schizoaffective disorder (N=26) received adherence assessments via electronically monitored medication vial caps as well as by monthly prescriber, patient, and research assistant report for up to six months. Results: Electronic monitoring detected greater nonadherence rates (57%) than either prescribers (7%) or patients (5%), though the research assistant ratings were 54%. No directional bias was found between electronic monitoring and assignment of adherence by research assistants, although disagreement occurred in 36% of cases. Conclusions: Both patients and prescribers grossly overestimated medication adherence, which may interfere with or reduce the effectiveness of diligent medication management.

Original languageEnglish (US)
Pages (from-to)844-847
Number of pages4
JournalPsychiatric Services
Volume58
Issue number6
DOIs
StatePublished - Jun 2007

Fingerprint

Medication Adherence
schizophrenia
assistant
Schizophrenia
medication
electronics
monitoring
Psychotic Disorders
Outpatients
rating
Research
Antipsychotic Agents
trend
management

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Public Health, Environmental and Occupational Health
  • Health(social science)
  • Health Professions(all)

Cite this

Validity of electronically monitored medication adherence and conventional adherence measures in schizophrenia. / Byerly, Matthew J.; Thompson, Ann; Carmody, Thomas; Bugno, Rhiannon; Erwin, Thomas; Kashner, Michael; Rush, A. John.

In: Psychiatric Services, Vol. 58, No. 6, 06.2007, p. 844-847.

Research output: Contribution to journalArticle

Byerly, Matthew J. ; Thompson, Ann ; Carmody, Thomas ; Bugno, Rhiannon ; Erwin, Thomas ; Kashner, Michael ; Rush, A. John. / Validity of electronically monitored medication adherence and conventional adherence measures in schizophrenia. In: Psychiatric Services. 2007 ; Vol. 58, No. 6. pp. 844-847.
@article{130c83a9feb3480986ed08fe43221dba,
title = "Validity of electronically monitored medication adherence and conventional adherence measures in schizophrenia",
abstract = "Objective: This study evaluated the validity of prescriber, patient, and research assistant ratings of adherence to prescribed oral antipsychotic medication among outpatients with schizophrenia or schizoaffective disorder in comparison with electronic monitoring. Methods: Adult outpatients with schizophrenia (N=35) or schizoaffective disorder (N=26) received adherence assessments via electronically monitored medication vial caps as well as by monthly prescriber, patient, and research assistant report for up to six months. Results: Electronic monitoring detected greater nonadherence rates (57{\%}) than either prescribers (7{\%}) or patients (5{\%}), though the research assistant ratings were 54{\%}. No directional bias was found between electronic monitoring and assignment of adherence by research assistants, although disagreement occurred in 36{\%} of cases. Conclusions: Both patients and prescribers grossly overestimated medication adherence, which may interfere with or reduce the effectiveness of diligent medication management.",
author = "Byerly, {Matthew J.} and Ann Thompson and Thomas Carmody and Rhiannon Bugno and Thomas Erwin and Michael Kashner and Rush, {A. John}",
year = "2007",
month = "6",
doi = "10.1176/appi.ps.58.6.844",
language = "English (US)",
volume = "58",
pages = "844--847",
journal = "Psychiatric Services",
issn = "1075-2730",
publisher = "American Psychiatric Association",
number = "6",

}

TY - JOUR

T1 - Validity of electronically monitored medication adherence and conventional adherence measures in schizophrenia

AU - Byerly, Matthew J.

AU - Thompson, Ann

AU - Carmody, Thomas

AU - Bugno, Rhiannon

AU - Erwin, Thomas

AU - Kashner, Michael

AU - Rush, A. John

PY - 2007/6

Y1 - 2007/6

N2 - Objective: This study evaluated the validity of prescriber, patient, and research assistant ratings of adherence to prescribed oral antipsychotic medication among outpatients with schizophrenia or schizoaffective disorder in comparison with electronic monitoring. Methods: Adult outpatients with schizophrenia (N=35) or schizoaffective disorder (N=26) received adherence assessments via electronically monitored medication vial caps as well as by monthly prescriber, patient, and research assistant report for up to six months. Results: Electronic monitoring detected greater nonadherence rates (57%) than either prescribers (7%) or patients (5%), though the research assistant ratings were 54%. No directional bias was found between electronic monitoring and assignment of adherence by research assistants, although disagreement occurred in 36% of cases. Conclusions: Both patients and prescribers grossly overestimated medication adherence, which may interfere with or reduce the effectiveness of diligent medication management.

AB - Objective: This study evaluated the validity of prescriber, patient, and research assistant ratings of adherence to prescribed oral antipsychotic medication among outpatients with schizophrenia or schizoaffective disorder in comparison with electronic monitoring. Methods: Adult outpatients with schizophrenia (N=35) or schizoaffective disorder (N=26) received adherence assessments via electronically monitored medication vial caps as well as by monthly prescriber, patient, and research assistant report for up to six months. Results: Electronic monitoring detected greater nonadherence rates (57%) than either prescribers (7%) or patients (5%), though the research assistant ratings were 54%. No directional bias was found between electronic monitoring and assignment of adherence by research assistants, although disagreement occurred in 36% of cases. Conclusions: Both patients and prescribers grossly overestimated medication adherence, which may interfere with or reduce the effectiveness of diligent medication management.

UR - http://www.scopus.com/inward/record.url?scp=34250791601&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=34250791601&partnerID=8YFLogxK

U2 - 10.1176/appi.ps.58.6.844

DO - 10.1176/appi.ps.58.6.844

M3 - Article

C2 - 17535946

AN - SCOPUS:34250791601

VL - 58

SP - 844

EP - 847

JO - Psychiatric Services

JF - Psychiatric Services

SN - 1075-2730

IS - 6

ER -